In disease, lung function and structure are heterogeneous, and aerosol transport and local
deposition vary significantly among parts of the lung. Understanding such heterogeneity is …

Abstract Background: A previous PET-CT imaging study of 14 bronchoconstricted asthmatic
subjects showed that peripheral aerosol deposition was highly variable among subjects and …

Background: This article presents a novel methodological approach to evaluate images of
aerosol deposition taken with PET-CT cameras. Traditionally, Black-or-White (BW) Regions …

Physiological conditions and pathophysiological changes in the lungs may affect many
applications in aerosol medicine and pulmonary drug delivery. In the diseased lung, spatial …

In this article, we address a fundamental question regarding computational fluid dynamics
(CFD) modeling within lung airways: does the inhaled volume during imaging have a …

Aerosol therapies are often used to treat lung diseases in which ventilation is distributed
heterogeneously throughout the lung. As therapeutic aerosols are transported by the …

Rationale: During severe bronchoconstriction bronchodilators are sometimes administered
in a mixture of 80% helium and 20% oxygen (He-O2) in an effort reduce the resistance in the …

Rationale: During bronchoconstriction in asthma, both ventilation and aerosol deposition are
heterogeneous; they vary both between and within lobes. The aim of this work was to …

In inhalation therapy, aerosol deposition studies play a significant role in developing our
understanding of the correlation between deposition site in the lungs and clinical effect to …

Three-dimensional positron emission tomography (PET) can be used to assess the spatial
distribution of inhaled aerosols, and with lung models of airway parameters this data can be …