Celecoxib and omega-3 fatty acids alone and in combination with risperidone affect the behavior and brain biochemistry in amphetamine-induced model of …

AES El-Sisi, SS Sokkar, MES El-Sayad… - Biomedicine & …, 2016 - Elsevier
The implications of oxidative stress and neuro-inflammation in the pathogenesis of
schizophrenia have been elucidated. Despite their effectiveness against positive symptoms …

Omega-3 prevents behavior response and brain oxidative damage in the ketamine model of schizophrenia

AI Zugno, HL Chipindo, AM Volpato, J Budni… - Neuroscience, 2014 - Elsevier
Supplementation with omega-3 has been identified as an adjunctive alternative for the
treatment of psychiatric disorders, in order to minimize symptoms. Considering the lack of …

The effects of celecoxib augmentation on cytokine levels in schizophrenia

CJ Bresee, K Delrahim, RE Maddux… - International Journal …, 2006 - academic.oup.com
Celecoxib augmentation therapy has been reported to enhance the rate of clinical response
for patients with schizophrenia. This may be due in part to an effect of celecoxib in the …

Adjunctive celecoxib for schizophrenia: a meta-analysis of randomized, double-blind, placebo-controlled trials

W Zheng, DB Cai, XH Yang, GS Ungvari, CH Ng… - Journal of psychiatric …, 2017 - Elsevier
Neuroinflammation has been implicated in the neurobiological pathways of schizophrenia.
This meta-analysis evaluated the efficacy and tolerability of adjunctive celecoxib as a …

Investigation of the protective effect of resveratrol in an MK-801-induced mouse model of schizophrenia

MS Akosman, R Türkmen, HH Demirel - Environmental Science and …, 2021 - Springer
Increasing evidence supports the view that oxidative stress and brain demyelination play an
important role in the pathogenesis of schizophrenia. Resveratrol is a powerful antioxidant …

Alpha-lipoic acid alone and combined with clozapine reverses schizophrenia-like symptoms induced by ketamine in mice: participation of antioxidant, nitrergic and …

GS Vasconcelos, NC Ximenes, CNS de Sousa… - Schizophrenia …, 2015 - Elsevier
Oxidative stress has important implications in schizophrenia. Alpha-lipoic acid (ALA) is a
natural antioxidant synthesized in human tissues with clinical uses. We studied the effect of …

Resveratrol plays Neuroprotective role on ketamine-induced schizophrenia-like behaviors and oxidative damage in mice

A Farkhakfar, S Hassanpour, M Zendehdel - Neuroscience Letters, 2023 - Elsevier
This study aimed to determine effects of the resveratrol on ketamine-induced schizophrenia-
like behaviors and oxidative damage in mice. Twenty-four male mice were allocated into …

Celecoxib as adjunctive therapy in schizophrenia: a double-blind, randomized and placebo-controlled trial

S Akhondzadeh, M Tabatabaee, H Amini… - Schizophrenia …, 2007 - Elsevier
Some evidence suggests that the pathophysiology of schizophrenia is associated with the
abnormal immune system, and cytokines may be important in schizophrenia …

Beneficial antipsychotic effects of celecoxib add-on therapy compared to risperidone alone in schizophrenia

N Müller, M Riedel, C Scheppach… - American Journal of …, 2002 - Am Psychiatric Assoc
OBJECTIVE: Abnormalities in the immune system in schizophrenia have been described.
However, important findings such as high levels of activating cytokines in the CSF and signs …

Advantages of the alpha-lipoic acid association with chlorpromazine in a model of schizophrenia induced by ketamine in rats: behavioral and oxidative stress …

LRL Sampaio, FMS Cysne Filho, JC de Almeida… - Neuroscience, 2018 - Elsevier
Schizophrenia is a chronic mental disorder reported to compromise about 1% of the world's
population. Although its pathophysiological process is not completely elucidated, evidence …