Mass Spectrometric Methods for Evaluation of Voriconazole Avian Pharmacokinetics and the Inhibition of its Cytochrome P450-induced Metabolism

AF Lehner, SD Johnson, L Dirikolu… - Toxicology …, 2024 - Taylor & Francis
Invasive fungal aspergillosis is a leading cause of morbidity and mortality in many species
including avian species such as common ravens (Corvus corax). Methods were developed …

Designing voriconazole treatment for racing pigeons: balancing between hepatic enzyme auto induction and toxicity

LA Beernaert, K Baert, P Marin, K Chiers… - Medical …, 2009 - academic.oup.com
Aspergillosis is a major cause of mortality in captive birds and its prognosis is often poor due
to treatment failure. Voriconazole is a novel triazole antifungal agent that may be useful for …

Plasma concentrations of voriconazole in falcons

V Schmidt, F Demiraj, A Di Somma, T Bailey… - Veterinary …, 2007 - Wiley Online Library
Doses of 12· 5 mg voriconazole/kg bodyweight administered every 12 hours by crop gavage
to six falcons for 14 days provided peak plasma concentrations of more than 1 μg/ml, but the …

Pharmacokinetics, tissue concentrations, and safety of the antifungal agent voriconazole in chickens

J Burhenne, WE Haefeli, M Hess, A Scope - Journal of Avian Medicine and …, 2008 - BioOne
Voriconazole, a highly potent triazole antifungal agent with high in vitro activity against a
wide variety of fungal pathogens, appears to be an option for the treatment of aspergillosis in …

Evaluation of the influence of formulation, food intake and species on voriconazole plasma concentration in birds.

J Burhenne, A Scope - 2012 - cabidigitallibrary.org
Voriconazole is currently recommended as first choice treatment for aspergillosis in birds. An
evaluation of the influence of food intake was performed with twelve African grey parrots …

Application of different pharmacokinetic models to describe and predict pharmacokinetics of voriconazole in magellanic penguins following oral administration

RA Parsley, AG Mutlow, J Hansted… - Journal of veterinary …, 2019 - Wiley Online Library
Aspergillosis is a condition causing serious morbidity and mortality in captive penguins and
other bird species. It can be treated with antifungal drugs, such as voriconazole. However …

Single oral or intravenous administration of voriconazole achieved recommended therapeutic minimum inhibitory concentrations against Aspergillus in the common …

SD Johnson, JP Buchweitz… - American Journal of …, 2022 - Am Vet Med Assoc
OBJECTIVE To determine the pharmacokinetics of voriconazole after single IV or orally
administered boluses in common ravens (Corvus corax). ANIMALS 8 healthy common …

Pharmacokinetics of voriconazole in adult mallard ducks (Anas platyrhynchos)

Y Kline, KV Clemons, L Woods, DA Stevens… - Medical …, 2011 - academic.oup.com
The pharmacokinetics of voriconazole (VRC) administered intravenously (IV) or orally (PO;
with and without liquid diet) to mallard ducks were studied. Dose range, drug bioavailability …

[PDF][PDF] Pharmacokinetics and pharmacodynamics of the new antifungal agent voriconazole in birds

A Scope, J Burhenne, WE Haefeli… - Proc Eur Assoc Avian …, 2005 - researchgate.net
ABSTRACT Voriconazole (Vfend®, Pfizer) is a novel, highly potent triazole antifungal agent
with high in vitro activity against a wide variety of fungal pathogens. The present study was …

Pharmacokinetics of a single dose of voriconazole administered orally with and without food to red-tailed hawks (Buteo jamaicensus)

RA Parsley, LA Tell, R Gehring - American Journal of Veterinary …, 2017 - Am Vet Med Assoc
OBJECTIVE To determine the pharmacokinetics of voriconazole administered PO with or
without food to red-tailed hawks (Buteo jamaicensus) and whether any observed variability …