Class-II major histocompatibility complexes (MHC-IIs) are central to the communications
between CD4+ T cells and antigen presenting cells (APCs), but intrinsic structural features …

Major Histocompatibility Complex class I (MHC-I) molecules display self, viral or aberrant
epitopic peptides to T cell receptors (TCRs), which employ interactions between …

Deeper understanding T-cell mediated adaptive immune responses bears important
implications in designing cancer immunotherapies and antiviral vaccines against pandemic …

Major histocompatibility class I (MHC-I) proteins mediate immunosurveillance against
pathogens and cancers by presenting antigenic or mutated peptides to antigen receptors of …

Abstract Major Histocompatibility Complex (MHC) plays a major role in the adaptive immune
response by recognizing foreign proteins through binding to their peptides. In humans alone …

Recombinant αβ T cell receptors, expressed on T cell membranes, recognize short peptides
presented at the cell surface in complex with MHC molecules. There are two main subsets of …

Antigen recognition followed by the activation of cytotoxic T-cells (CTLs) is a key step in
adaptive immunity, resulting in clearance of viruses and cancers. The repertoire of peptides …

T-cell receptor-mimetic antibodies (TCRms) targeting disease-associated peptides
presented by Major Histocompatibility Complexes (pMHCs) are set to become a major new …

Background The adaptive immune response is antigen-specific and triggered by pathogen
recognition through T cells. Although the interactions and mechanisms of TCR-peptide-MHC …

Successful immunity requires that a limited pool of αβ T-cell receptors (TCRs) provide cover
for a vast number of potential foreign peptide antigens presented by 'self'major …