Background The adaptive immune response is antigen-specific and triggered by pathogen
recognition through T cells. Although the interactions and mechanisms of TCR-peptide-MHC …

Successful immunity requires that a limited pool of αβ T-cell receptors (TCRs) provide cover
for a vast number of potential foreign peptide antigens presented by 'self'major …

Major Histocompatibility Complex (MHC) I and II and the αβ T-cell antigen receptor (TCRαβ)
govern fundamental traits of adaptive immunity. They form a membrane-borne ligand …

Deeper understanding of T-cell-mediated adaptive immune responses is important for the
design of cancer immunotherapies and antiviral vaccines against pandemic outbreaks. T …

The majority of known major histocompatibility complex class I (MHCI)-associated tumor-
derived peptide antigens do not contain an optimal motif for MHCI binding. As a result …

Rational vaccine development and evaluation requires identifying and measuring the
magnitude of epitope-specific CD8 T cell responses. However, conventional CD8 T cell …

Identification of CD8+ T cell epitopes is critical for the development of immunotherapeutics.
Existing methods for major histocompatibility complex class I (MHC class I) ligand discovery …

Major histocompatibility complex (MHC) class I molecules present short peptide ligands on
the cell surface for interrogation by cytotoxic CD8+ T cells. MHC class I complexes …

Class II MHC molecules display peptides on the cell surface for the surveillance by CD4+ T
cells. To ensure that these ligands accurately reflect the content of the intracellular MHC …

CD8+ cytotoxic T cell responses against viral infection represent a major element of the
adaptive immune response. We describe the development of a peptide antigen–major …