Short peptides derived from cellular proteins may escape complete destruction during
protein catabolism and finally serve as a showcase in the immune system. Exposed at the …

Understanding peptide presentation by specific MHC alleles is fundamental for controlling
physiological functions of T cells and harnessing them for therapeutic use. However …

Despite the need to monitor the impact of Cancer Immunotherapy (CI)/Immuno‐Oncology
(IO) therapeutics on neoantigen‐specific T‐cell responses, very few clinical programs …

The promiscuous nature of T-cell receptors (TCRs) allows T cells to recognize a large variety
of pathogens, but makes it challenging to understand and control T-cell recognition. Existing …

T-cell specificity to differentiate between self and non-self relies on T-cell receptor (TCR)
recognition of peptides presented by the Major Histocompatibility Complex (MHC) …

Recognition of antigenic peptides bound to major histocompatibility complex (MHC) proteins
by αβ T cell receptors (TCRs) is a hallmark of T cell mediated immunity. Recent data suggest …

T cell receptor (TCR)-based therapeutic cells and agents (eg adoptive T cell,, TCR-
engineered T cells, ImmTACs, TCR mimic antibodies, neoantigen vaccines,) have emerged …

Abstract αβ T cell receptors (TCRs) recognize peptides presented by major
histocompatibility complex (MHC) proteins using multiple complementarity-determining …

Class I major histocompatibility complex proteins play a critical role in the adaptive immune
system by binding to peptides derived from cytosolic proteins and presenting them on the …

Although the major histocompatibility complex class I (MHC-I) molecules typically bind short
peptide (p) fragments (8–10 amino acids in length), longer," bulged" peptides are often be …