HDAC2 counteracts vascular calcification by activating autophagy in chronic kidney disease

G Zhou, P Liu, C Zhang, Q Huang, Z Zhao… - The FASEB …, 2024 - Wiley Online Library
Vascular calcification is a major risk factor for cardiovascular disease mortality, with a
significant prevalence in chronic kidney disease (CKD). Pharmacological inhibition of …

Hdac9 inhibits medial artery calcification through down-regulation of Osterix

P He, H Yu, L Jiang, Z Chen, S Wang, VE Macrae… - Vascular …, 2020 - Elsevier
Backgrounds Medial artery calcification (MAC) significantly contributes to the increased
cardiovascular death in patients with chronic kidney disease (CKD). Previous genome-wide …

Histone Deacetylase 9 Contributes to Vascular Calcification in CKD: SA-PO773

L Xiong, Q Xiao, C Rong, Y Tang, L Wang… - Journal of the …, 2022 - journals.lww.com
Background: Vascular calcification (VC) is a serious complication of chronic kidney disease
(CKD). Unfortunately, there is no effective therapy for VC beyond supportive care due to the …

HDAC1‐mediated deacetylation of LSD1 regulates vascular calcification by promoting autophagy in chronic renal failure

J Zhou, H Zhou, C Liu, L Huang, D Lu… - Journal of Cellular and …, 2020 - Wiley Online Library
Chronic renal failure (CRF) is commonly associated with various adverse consequences
including pathological vascular calcification (VC), which represents a significant clinical …

MDM2 E3 ligase-mediated ubiquitination and degradation of HDAC1 in vascular calcification

H Kook, DH Kwon, GH Eom, S Shin… - …, 2016 - atherosclerosis-journal.com
Objectives: Vascular calcification (VC) is often associated with cardiovascular and metabolic
diseases. However, the molecular mechanisms linking VC to these diseases have yet to be …

Downregulation of HDAC9 by the ketone metabolite β‐hydroxybutyrate suppresses vascular calcification

Z Lan, A Chen, L Li, Y Ye, Q Liang… - The Journal of …, 2022 - Wiley Online Library
Vascular calcification is an actively regulated process resembling bone formation and
contributes to the cardiovascular morbidity and mortality of chronic kidney disease (CKD) …

Downregulation of Histone Deacetylase 9 (HDAC9) is Associated with Vascular Calcification in Diabetic Mice.

SA Benerofe, MA Carrillo‐Sepulveda - The FASEB Journal, 2017 - Wiley Online Library
Vascular complications, including calcification, are some of the major problems faced by
type 2 diabetic (T2DM) patients. In fact, the majority of these diabetic patients will die due to …

[HTML][HTML] MDM2 E3 ligase-mediated ubiquitination and degradation of HDAC1 in vascular calcification

DH Kwon, GH Eom, JH Ko, S Shin, H Joung… - Nature …, 2016 - nature.com
Vascular calcification (VC) is often associated with cardiovascular and metabolic diseases.
However, the molecular mechanisms linking VC to these diseases have yet to be elucidated …

Histone deacetylase 3 plays a critical role in hypertension-induced kidney inflammation and fibrosis

C An, B Jiao, H Du, M Tran, B Song, P Wang, Z Hu… - bioRxiv, 2023 - biorxiv.org
Objective: Hypertension is a major cause of chronic kidney disease. The molecular
mechanisms how hypertension causes kidney disease are not fully understood. In this study …

[HTML][HTML] Roles of histone acetylation modifiers and other epigenetic regulators in vascular calcification

DH Kwon, J Ryu, YK Kim, H Kook - International journal of molecular …, 2020 - mdpi.com
Vascular calcification (VC) is characterized by calcium deposition inside arteries and is
closely associated with the morbidity and mortality of atherosclerosis, chronic kidney …