Gastric cancer remains a significant health burden worldwide. In continuation of our
previous study and development of effective small molecules against gastric cancer, a series …

Gastric cancer remains one of the most common deadly diseases and lacks effective
targeted therapies. In the present study, we confirmed that the signal transducer and …

Background: Gastric cancer is one of the most commonly diagnosed cancers each year, and
it remains the third leading cause of cancer death in the world. The clinicopathologic …

Signal transducer and activator of transcription 3 (STAT3) plays a key role in promoting
tumor malignant progression. Suppression of hyperactivated STAT3 signaling has emerged …

Signal transducer and activator of transcription 3 (STAT3) is a key regulator of many human
cancers and has been widely recognized as a promising target for cancer therapy. A variety …

Gastric cancer is a common type of malignant tumor with a relatively poor prognosis and
presents a serious threat to global health. Signal Transducer and Activator of Transcription-3 …

Gastric cancer is the third leading cause of cancer‑associated deaths worldwide. Research
into the underlying mechanisms of gastric cancer is essential for the development of novel …

The cumulative evidence supports STAT3, a transcriptional mediator of oncogenic signaling,
as a therapeutic target in cancer. The development of STAT3 inhibitors remain an active …

A new series of 20 brominated chalcone derivatives were designed, synthesized, and
investigated for their effects against the growth of four cancer cell lines (EC109, SKNSH …

Background Aberrant activation of the signal transducer and activator of transcription 3
(STAT3) is frequently seen in patients with gastric cancer (GC), and is generally associated …