Double-strand DNA breaks (DSBs) are toxic to cells, and improper repair can cause
chromosomal abnormalities that initiate and drive cancer progression. DNA ligases III and IV …

DNA double strand breaks (DSBs) are induced by external genotoxic agents (ionizing
radiation or genotoxins) or by internal processes (recombination intermediates in …

Humans have three genes encoding DNA ligases with conserved structural features and
activities, but they also have notable differences. The LIG3 gene encodes a ubiquitous …

Higher eukaryotes have three types of DNA ligases: DNA ligase 1 (Lig1), DNA ligase 3
(Lig3) and DNA ligase 4 (Lig4). While Lig1 and Lig4 are present in all eukaryotes from yeast …

Among the mammalian genes encoding DNA ligases (LIG), the LIG3 gene is unique in that it
encodes multiple DNA ligase polypeptides with different cellular functions. Notably, this …

In eukaryotes, the three families of ATP-dependent DNA ligases are associated with specific
functions in DNA metabolism. DNA ligase I (LigI) catalyzes Okazaki-fragment ligation at the …

Of the three DNA ligases present in all vertebrates, DNA ligase I (Lig1) has been considered
essential for ligating Okazaki fragments during DNA replication and thereby essential for cell …

To ensure genome integrity, the joining of breaks in the phosphodiester backbone of duplex
DNA is required during DNA replication and to complete the repair of almost all types of …

The joining of DNA strand breaks by DNA ligases is required to seal Okazaki fragments
during DNA replication and to complete almost all DNA repair pathways. In human cells …

Abstract Mammalian DNA ligase III (LigIII) functions in both nuclear and mitochondrial DNA
metabolism. In the nucleus, LigIII has functional redundancy with DNA ligase I whereas LigIII …