Background NOD-like receptors (NLR) are intracellular sensors of the innate immune
system, with the NLRP3 being a pro-inflammatory member that modulates cardiac ischemia …

Mitochondrial dysfunction is the most prominent source of oxidative stress in acute and
chronic kidney disease. NLRX1 is a receptor of the innate immune system that is …

Increasing evidence suggests that inflammation and apoptosis are involved in the
development of acute myocardial ischemia (AMI). Nucleotide-binding oligomerization …

Significance: Persistent nonmicrobial tissue injury leads to the nonlinear activation of
integrated wound-healing pathways. In chronic cardiovascular diseases, local tissue …

Several metabolic, cardiovascular, and neurological disorders are characterized by
mitochondrial dysfunction followed by dysregulation of cellular energetics. Mitochondria play …

NLRX1 is a member of the NOD‐like receptor family, a set of pattern recognition receptors
associated with innate immunity. Interestingly, NLRX1 exists in somewhat of an exile from its …

The Nlrp3 inflammasome is a protein complex consisting of NLRP3, ASC and caspase-1,
that upon activation produces a potent proinflammatory cytokine, IL-1β. Evidence has …

An accumulating body of evidence has indicated that inflammation in the absence of
pathogens, which is referred to as sterile inflammation, is mediated through an …

Cells utilize a diverse repertoire of cell surface and intracellular receptors to detect
exogenous or endogenous danger signals and even the changes of their microenvironment …

The metabolic syndrome could be induced by high fat diet, leading to cardiovascular
diseases, such as myocardial damage. Inflammation response and oxidative stress have …