[HTML][HTML] The immune regulatory role of protein kinase CK2 and its implications for treatment of cancer

H Hong, EN Benveniste - Biomedicines, 2021 - mdpi.com
Protein Kinase CK2, a constitutively active serine/threonine kinase, fulfills its functions via
phosphorylating hundreds of proteins in nearly all cells. It regulates a variety of cellular …

Protein kinase 2 (CK2): A potential regulator of immune cell development and function in cancer

K Husain, TT Williamson, N Nelson… - Immunological …, 2021 - Taylor & Francis
Protein kinase CK2, formally known as casein kinase II, is ubiquitously expressed and highly
conserved serine/threonine or tyrosine kinase enzyme that regulates diverse signaling …

Protein kinase CK2 controls CD8+ T cell effector and memory function during infection

W Yang, H Wei, GA Benavides, WJ Turbitt… - The Journal of …, 2022 - journals.aai.org
Protein kinase CK2 is a serine/threonine kinase composed of two catalytic subunits (CK2α
and/or CK2α′) and two regulatory subunits (CK2β). CK2 promotes cancer progression by …

Protein kinase CK2: an emerging regulator of immunity

SA Gibson, EN Benveniste - Trends in immunology, 2018 - cell.com
Although it has historically been studied in the context of cancer, recent literature has
highlighted the importance of the highly conserved serine/threonine kinase casein kinase II …

[HTML][HTML] Therapeutic targeting of CK2 in acute and chronic leukemias

F Buontempo, JA McCubrey, E Orsini, M Ruzzene… - Leukemia, 2018 - nature.com
CK2 is a ubiquitously expressed, constitutively active Ser/Thr protein kinase, which is
considered the most pleiotropic protein kinase in the human kinome. Such a pleiotropy …

Emergence of protein kinase CK2 as a key target in cancer therapy

JH Trembley, Z Chen, G Unger, J Slaton, BT Kren… - Biofactors, 2010 - Wiley Online Library
Protein kinase CK2, a protein serine/threonine kinase, plays a global role in activities related
to cell growth, cell death, and cell survival. CK2 has a large number of potential substrates …

Protein kinase CK2 cellular function in normal and disease states

K Ahmed, OG Issinger, R Szyszka - 2015 - Springer
The selection of “Protein Kinase CK2 Cellular Function in Normal and Disease State,” as
part of the Springer series “Advances in Biochemistry in Health and Disease”(Volume 12) …

Protein kinase CK2 in hematologic malignancies: reliance on a pivotal cell survival regulator by oncogenic signaling pathways

F Piazza, S Manni, M Ruzzene, LA Pinna, C Gurrieri… - Leukemia, 2012 - nature.com
CK2 is a multitask kinase whose role is essential for a countless number of cellular
processes, many of which are critical for blood cell development. A prevailing task for this …

[HTML][HTML] Myeloid cell CK2 regulates inflammation and resistance to bacterial infection

SR Larson, N Bortell, A Illies, WJ Crisler… - Frontiers in …, 2020 - frontiersin.org
Kinase activity plays an essential role in the regulation of immune cell defenses against
pathogens. The protein kinase CK2 (formerly casein kinase II) is an evolutionarily conserved …

[HTML][HTML] Protein kinase CK2–diverse roles in cancer cell biology and therapeutic promise

JH Trembley, BT Kren, M Afzal, GA Scaria… - Molecular and cellular …, 2023 - Springer
The association of protein kinase CK2 (formerly casein kinase II or 2) with cell growth and
proliferation in cells was apparent at early stages of its investigation. A cancer-specific role …