[HTML][HTML] The immune regulatory role of protein kinase CK2 and its implications for treatment of cancer
H Hong, EN Benveniste - Biomedicines, 2021 - mdpi.com
Protein Kinase CK2, a constitutively active serine/threonine kinase, fulfills its functions via
phosphorylating hundreds of proteins in nearly all cells. It regulates a variety of cellular …
phosphorylating hundreds of proteins in nearly all cells. It regulates a variety of cellular …
Protein kinase 2 (CK2): A potential regulator of immune cell development and function in cancer
K Husain, TT Williamson, N Nelson… - Immunological …, 2021 - Taylor & Francis
Protein kinase CK2, formally known as casein kinase II, is ubiquitously expressed and highly
conserved serine/threonine or tyrosine kinase enzyme that regulates diverse signaling …
conserved serine/threonine or tyrosine kinase enzyme that regulates diverse signaling …
Protein kinase CK2 controls CD8+ T cell effector and memory function during infection
W Yang, H Wei, GA Benavides, WJ Turbitt… - The Journal of …, 2022 - journals.aai.org
Protein kinase CK2 is a serine/threonine kinase composed of two catalytic subunits (CK2α
and/or CK2α′) and two regulatory subunits (CK2β). CK2 promotes cancer progression by …
and/or CK2α′) and two regulatory subunits (CK2β). CK2 promotes cancer progression by …
Protein kinase CK2: an emerging regulator of immunity
SA Gibson, EN Benveniste - Trends in immunology, 2018 - cell.com
Although it has historically been studied in the context of cancer, recent literature has
highlighted the importance of the highly conserved serine/threonine kinase casein kinase II …
highlighted the importance of the highly conserved serine/threonine kinase casein kinase II …
[HTML][HTML] Therapeutic targeting of CK2 in acute and chronic leukemias
F Buontempo, JA McCubrey, E Orsini, M Ruzzene… - Leukemia, 2018 - nature.com
CK2 is a ubiquitously expressed, constitutively active Ser/Thr protein kinase, which is
considered the most pleiotropic protein kinase in the human kinome. Such a pleiotropy …
considered the most pleiotropic protein kinase in the human kinome. Such a pleiotropy …
Emergence of protein kinase CK2 as a key target in cancer therapy
JH Trembley, Z Chen, G Unger, J Slaton, BT Kren… - Biofactors, 2010 - Wiley Online Library
Protein kinase CK2, a protein serine/threonine kinase, plays a global role in activities related
to cell growth, cell death, and cell survival. CK2 has a large number of potential substrates …
to cell growth, cell death, and cell survival. CK2 has a large number of potential substrates …
Protein kinase CK2 cellular function in normal and disease states
The selection of “Protein Kinase CK2 Cellular Function in Normal and Disease State,” as
part of the Springer series “Advances in Biochemistry in Health and Disease”(Volume 12) …
part of the Springer series “Advances in Biochemistry in Health and Disease”(Volume 12) …
Protein kinase CK2 in hematologic malignancies: reliance on a pivotal cell survival regulator by oncogenic signaling pathways
CK2 is a multitask kinase whose role is essential for a countless number of cellular
processes, many of which are critical for blood cell development. A prevailing task for this …
processes, many of which are critical for blood cell development. A prevailing task for this …
[HTML][HTML] Myeloid cell CK2 regulates inflammation and resistance to bacterial infection
SR Larson, N Bortell, A Illies, WJ Crisler… - Frontiers in …, 2020 - frontiersin.org
Kinase activity plays an essential role in the regulation of immune cell defenses against
pathogens. The protein kinase CK2 (formerly casein kinase II) is an evolutionarily conserved …
pathogens. The protein kinase CK2 (formerly casein kinase II) is an evolutionarily conserved …
[HTML][HTML] Protein kinase CK2–diverse roles in cancer cell biology and therapeutic promise
JH Trembley, BT Kren, M Afzal, GA Scaria… - Molecular and cellular …, 2023 - Springer
The association of protein kinase CK2 (formerly casein kinase II or 2) with cell growth and
proliferation in cells was apparent at early stages of its investigation. A cancer-specific role …
proliferation in cells was apparent at early stages of its investigation. A cancer-specific role …