Purpose This study aims to identify genetic causes of female infertility associated with
recurrent failure of assisted reproductive technology (ART) characterized by embryonic …

Early embryonic arrest is one of the major causes of female infertility. However, because of
difficulties in phenotypic evaluation, genetic determinants of human early embryonic arrest …

Background It has been proved that mutations in the PADI6 gene can cause early embryo
arrest. This study describes a newly discovered mutation in PADI6 that expands the genetic …

Purpose To investigate the pathogenesis of the recurrent preimplantation embryonic arrest
characterized by direct cleavage. Methods Two affected individuals underwent time-lapse …

Purpose The present study was intended to identify genetic causes of infertile patients with
recurrent failure of in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) attempts …

Background Oocytes have a lot of maternal RNAs and proteins, which are used by the early
embryo before zygotic genome activation. Transducin‐like enhancer of split 6 (TLE6) is a …

Recurrent hydatidiform moles (RHM) are aberrant human pregnancies characterized by
absence of, or abnormal, embryonic development, hydropic degeneration of chorionic villi …

The article discusses the identification of a human knockout phenotype caused by PAD16
homozygous inactivation. Particular focus is given to the intracytoplasmic sperm injection …

Successful human reproduction initiates from normal gamete formation, fertilization and
early embryonic development. Abnormalities in any of these steps will lead to infertility …

Preimplantation embryonic lethality is a rare cause of primary female infertility. It has been
reported that variants in the transducin-like enhancer of split 6 (TLE6) gene can lead to …