Immune classification for the PD-L1 expression and tumour-infiltrating lymphocytes in colorectal adenocarcinoma
BJ Noh, JY Kwak, DW Eom - BMC cancer, 2020 - Springer
Background Colorectal adenocarcinoma is the third most common cancer worldwide and a
leading cause of cancer-related death. The recent emergence of diverse immunotherapeutic …
leading cause of cancer-related death. The recent emergence of diverse immunotherapeutic …
Tumor microenvironment classification based on T‑cell infiltration and PD‑L1 in patients with mismatch repair‑proficient and‑deficient colorectal cancer
S Liu, P Kong, X Wang, L Yang, C Jiang… - Oncology …, 2019 - spandidos-publications.com
The classification of tumor microenvironments according to the presence or absence of
tumor infiltrating lymphocytes (TILs) and programmed death ligand‑1 (PD‑L1) expression …
tumor infiltrating lymphocytes (TILs) and programmed death ligand‑1 (PD‑L1) expression …
[PDF][PDF] Heterogeneity of PD-L1 expression and CD8 lymphocyte infiltration in metastatic colorectal cancer and their prognostic significance
H Xin, C Zhou, G Wang, Y Liu, J Zhang, Y Liu, B Li… - Heliyon, 2023 - cell.com
Purpose In recent years, immune checkpoint inhibitors have become a major therapeutic
method for the treatment of metastatic colorectal cancer (mCRC). Growing evidence …
method for the treatment of metastatic colorectal cancer (mCRC). Growing evidence …
Prognostic impact of programed cell death-1 (PD-1) and PD-ligand 1 (PD-L1) expression in cancer cells and tumor infiltrating lymphocytes in colorectal cancer
Y Li, L Liang, W Dai, G Cai, Y Xu, X Li, Q Li, S Cai - Molecular cancer, 2016 - Springer
Background Colorectal cancer (CRC) is 3rd most commonly diagnosed cancer in males and
the second in females. PD-1/PD-L1 axis, as an immune checkpoint, is up-regulated in many …
the second in females. PD-1/PD-L1 axis, as an immune checkpoint, is up-regulated in many …
PD-L1 expression in colorectal adenocarcinoma is associated with the tumor immune microenvironment and epithelial-mesenchymal transition
IE Secinti, T Ozgur, I Dede - American Journal of Clinical …, 2022 - academic.oup.com
Objectives Colorectal carcinomas are the third-most common tumors in the world, and
colorectal cancer ranks second in cancer-related deaths. Our aim in this study was to …
colorectal cancer ranks second in cancer-related deaths. Our aim in this study was to …
Comparative analysis and in vitro experiments of signatures and prognostic value of immune checkpoint genes in colorectal cancer
R Ma, X Qu, X Che, B Yang, C Li, K Hou… - OncoTargets and …, 2021 - Taylor & Francis
Purpose Immune checkpoints, as pivotal regulators of immune escape in cancer, can
motivate the emergence of immune checkpoint inhibitors (ICIs). The aim of this study is to …
motivate the emergence of immune checkpoint inhibitors (ICIs). The aim of this study is to …
Spatially resolved multimarker evaluation of CD274 (PD-L1)/PDCD1 (PD-1) immune checkpoint expression and macrophage polarisation in colorectal cancer
H Elomaa, M Ahtiainen, SA Väyrynen, S Ogino… - British Journal of …, 2023 - nature.com
Abstract Background The CD274 (PD-L1)/PDCD1 (PD-1) immune checkpoint interaction
may promote cancer progression, but the expression patterns and prognostic significance of …
may promote cancer progression, but the expression patterns and prognostic significance of …
Programmed death ligand 1 (PD-L1) in colon cancer and its interaction with budding and tumor-infiltrating lymphocytes (TILs) as tumor-host antagonists
C Lang-Schwarz, B Melcher, A Hartmann… - International Journal of …, 2021 - Springer
Purpose To analyze the role of programmed death ligand 1 (PD-L1) immunohistochemisty in
the context of tumor microenvironment in colon cancer (CC) with focus on the interaction …
the context of tumor microenvironment in colon cancer (CC) with focus on the interaction …
TIME (Tumor Immunity in the MicroEnvironment) classification based on tumor CD274 (PD-L1) expression status and tumor-infiltrating lymphocytes in colorectal …
T Hamada, TR Soong, Y Masugi, K Kosumi… - …, 2018 - Taylor & Francis
Inhibitors targeting the PDCD1 (programmed cell death 1, PD-1) immune checkpoint
pathway have revolutionized cancer treatment strategies. The TIME (Tumor Immunity in the …
pathway have revolutionized cancer treatment strategies. The TIME (Tumor Immunity in the …
The expression of immune checkpoint receptors and ligands in the colorectal cancer tumor microenvironment
P Neupane, K Mimura, S Nakajima… - Anticancer …, 2021 - ar.iiarjournals.org
Background/Aim: The limited efficacy of immune checkpoint inhibitors in colorectal cancer
(CRC) is likely due to immunosuppressive mechanisms including T cell exhaustion caused …
(CRC) is likely due to immunosuppressive mechanisms including T cell exhaustion caused …