Carbon monoxide and its role in human physiology: a brief historical perspective

K Kashfi, KK Patel - Biochemical Pharmacology, 2022 - Elsevier
Carbon monoxide is a molecule with notoriety in modern culture and extensive
documentation regarding its toxic physiological effects, long predating its formal discovery in …

Carbon monoxide is not always a poison gas for human organism: Physiological and pharmacological features of CO

B Olas - Chemico-biological interactions, 2014 - Elsevier
Carbon monoxide (CO) is an odorless, colorless and non-irritating gas. Even a small amount
of CO exposure is possibly associated with specific toxic effects. CO is also produced …

Carbon Monoxide as a Potential Therapeutic Agent: A Molecular Analysis of Its Safety Profiles

S Bansal, D Liu, Q Mao, N Bauer… - Journal of Medicinal …, 2024 - ACS Publications
Carbon monoxide (CO) is endogenously produced in mammals, with blood concentrations
in the high micromolar range in the hemoglobin-bound form. Further, CO has shown …

Carbon monoxide: endogenous production, physiological functions, and pharmacological applications

L Wu, R Wang - Pharmacological reviews, 2005 - ASPET
Over the last decade, studies have unraveled many aspects of endogenous production and
physiological functions of carbon monoxide (CO). The majority of endogenous CO is …

A brief history of carbon monoxide and its therapeutic origins

CP Hopper, PN Zambrana, U Goebel, J Wollborn - Nitric Oxide, 2021 - Elsevier
It is estimated that 10% of carbon throughout the cosmos is in the form of carbon monoxide
(CO). Earth's earliest prebiotic atmosphere included the trinity of gasotransmitters CO, nitric …

The evolution of carbon monoxide into medicine

LE Otterbein - Respiratory care, 2009 - rc.rcjournal.com
The discovery that carbon monoxide (CO)—a highly publicized toxic gas molecule—can
have powerful benefits and curative effects not only changed how we view CO, but has, with …

Biological and pharmacological properties of carbon monoxide: a general overview

A Bilska-Wilkosz, M Górny, M Iciek - Oxygen, 2022 - mdpi.com
Carbon monoxide (CO) is one of the most common causes of inhalation poisoning
worldwide. However, it is also well known that CO is produced endogenously in the heme …

Carbon monoxide: a critical quantitative analysis and review of the extent and limitations of its second messenger function

DG Levitt, MD Levitt - Clinical pharmacology: Advances and …, 2015 - Taylor & Francis
Endogenously produced carbon monoxide (CO) is commonly believed to be a ubiquitous
second messenger involved in a wide range of physiological and pathological responses …

Carbon monoxide in biology and medicine

SW Ryter, LE Otterbein - Bioessays, 2004 - Wiley Online Library
Carbon monoxide (CO), a product of organic oxidation processes, arises in vivo during
cellular metabolism, most notably heme degradation. CO binds to the heme iron of most …

Carbon monoxide and human disease

D Morse, J Sethi - Antioxidants and Redox Signaling, 2002 - liebertpub.com
Carbon monoxide is produced endogenously in humans through the breakdown of
hemoglobin by heme oxygenase. Although originally thought to be a superfluous by-product …