Studies of methamphetamine (Meth)-induced neurotoxicity have traditionally focused on
monoaminergic terminal damage while more recent studies have found that stress …

Background Traumatic brain injury (TBI) is a worldwide health problem, identified as a major
cause of death and disability. Increasing evidence has shown that oxidative stress plays an …

Acute exposure to high altitudes can cause neurological dysfunction due to decreased
oxygen availability to the brain. In this study, the protective effects of Huperzine A on …

Traumatic brain injury (TBI) is a major leading cause of death and long-term disability.
Although astrocytes play a key role in neuroprotection after TBI in the early stage, the …

Hypobaric hypoxia (HH) exposure can cause serious brain injury as well as life-threatening
cerebral edema in severe cases. Previous studies on the mechanisms of HH-induced brain …

In astrocytes, carbon monoxide (CO) poisoning causes oxidative stress and mitochondrial
dysfunction accompanied by caspase and calpain activation. Impairment in astrocyte …

Hypobaric hypoxia (HH) induced neurodegeneration has been attributed to several factors
including increased oxidative stress, glutamate excitotoxicity, decreased growth factors …

Background There is no effective therapeutic intervention developed targeting
cerebrovascular toxicity of drugs of abuse, including methamphetamine (METH). We …

High altitude hypobaric hypoxia (HH) affects prefrontal cognitive and executive functions.
Guanfacine, alpha 2A adrenoceptor agonist ameliorates the neurological outcomes of high …

Oxidative stress plays an important role in the secondary neuronal damage after traumatic
brain injury (TBI). Inhibition of histone deacetylases (HDACs) has been shown to reduce …