Background Comparative clinical effects of balanced crystalloids and saline are uncertain,
particularly in noncritically ill patients cared for outside an intensive care unit (ICU). Methods …

Background Both balanced crystalloids and saline are used for intravenous fluid
administration in critically ill adults, but it is not known which results in better clinical …

Rationale: Saline is the intravenous fluid most commonly administered to critically ill adults,
but it may be associated with acute kidney injury and death. Whether use of balanced …

Background: The optimal resuscitative fluid remains controversial. Objective: To assess the
association between crystalloid fluid and outcomes in critically ill adults. Methods …

Intravenous fluid therapy is the most common intervention received by acutely ill patients.
Historically, saline (0.9% sodium chloride) has been the most frequently administered …

Rationale: Administration of intravenous crystalloid solutions is a fundamental therapy for
sepsis, but the effect of crystalloid composition on patient outcomes remains unknown …

Background The comparative efficacy and safety of balanced crystalloid solutions and saline
for fluid therapy in critically ill adults remain uncertain. Methods We systematically reviewed …

Rationale: The effects of balanced crystalloid versus saline on clinical outcomes for ICU
patients may be modified by the type of fluid that patients received for initial resuscitation …

Background The effect of balanced crystalloids compared with that of saline in critically ill
patients overall and in specific subgroups is unclear. We aimed to assess whether use of …

Objective: Isotonic saline is the most commonly used crystalloid in the ICU, but recent
evidence suggests that balanced fluids like Lactated Ringer's solution may be preferable …