The aging immune system is unable to optimally respond to pathogens and generate long-
term immunological memory against encountered antigens. Amongst the immune …

It is well known that aging is associated with dysregulated metabolism. This is seen both in
terms of systemic metabolism, as well as at the cellular level with clear mitochondrial …

Mitochondria are ancient organelles that have co-evolved with their cellular hosts,
developing a mutually beneficial arrangement. In addition to making energy, mitochondria …

T cell-mediated immune responses are compromised in aged individuals, leading to
increased morbidity and reduced response to vaccination. While cellular metabolism tightly …

Beginning with the sixth decade of life, the human immune system undergoes dramatic
aging-related changes, which continuously progress to a state of immunosenescence. The …

Aging results in remodeling of T cell immunity and is associated with poor clinical outcomes
in age-related diseases such as cancer. Among the hallmarks of aging, changes in host and …

Age impacts alloimmunity. Effects of aging on T‐cell metabolism and the potential to
interfere with immunosuppressants have not been explored yet. Here, we dissected …

T cell survival, differentiation after stimulation, and function are intrinsically linked to distinct
cellular metabolic states. The ability of T cells to readily transition between metabolic states …

It is now clear that access to specific metabolic programmes controls the survival and
function of various immune cell populations, including T cells. Efficient naïve and memory T …

Mitochondrial dysfunction is a hallmark of aging that contributes to inflammaging. It is
characterized by alterations of the mitochondrial DNA, reduced respiratory capacity …