Therapeutic targeting of IL-6 trans-signaling

S Rose-John - Cytokine, 2021 - Elsevier
Abstract Interleukin-6 (IL-6) is a cytokine, which is involved in innate and acquired immunity,
in neural cell maintenance and in metabolism. IL-6 can be synthesized by many different …

[HTML][HTML] IL-6 trans-signaling via the soluble IL-6 receptor: importance for the pro-inflammatory activities of IL-6

S Rose-John - International journal of biological sciences, 2012 - ncbi.nlm.nih.gov
Abstract Interleukin-6 (IL-6) is a cytokine with many activities. It has functions in the
regulation of the immune system and the nervous system. Furthermore, IL-6 is involved in …

Dissecting interleukin-6 classic-and trans-signaling in inflammation and cancer

C Garbers, S Rose-John - Inflammation and Cancer: Methods and …, 2018 - Springer
Interleukin-6 is a cytokine synthesized by many cells in the human body. IL-6 binds to a
membrane bound IL-6R, which is only present on hepatocytes, some epithelial cells and …

Interleukin-6: Biology, signaling and strategies of blockade

F Schaper, S Rose-John - Cytokine & growth factor reviews, 2015 - Elsevier
Abstract Interleukin-6 (IL-6) is one of the most important inflammatory cytokines. IL-6 is
unique in signaling via a membrane bound and a soluble receptor. Intriguingly, these two …

Blocking only the bad side of IL-6 in inflammation and cancer

S Rose-John - Cytokine, 2021 - Elsevier
Abstract Interleukin-6 (IL-6) is considered an inflammatory cytokine, which is involved not
only in most inflammatory states but it also plays a prominent role in inflammation associated …

Interleukin-6 biology is coordinated by membrane-bound and soluble receptors: role in inflammation and cancer

S Rose-John, J Scheller, G Elson… - Journal of leukocyte …, 2006 - academic.oup.com
Cytokine receptors, which exist in membrane-bound and soluble forms, bind their ligands
with comparable affinity. Although most soluble receptors are antagonists and compete with …

[HTML][HTML] Targeting IL-6 trans-signalling: past, present and future prospects

S Rose-John, BJ Jenkins, C Garbers, JM Moll… - Nature Reviews …, 2023 - nature.com
Abstract Interleukin-6 (IL-6) is a key immunomodulatory cytokine that affects the
pathogenesis of diverse diseases, including autoimmune diseases, chronic inflammatory …

Interleukin-6: a masterplayer in the cytokine network

P Uciechowski, W Dempke - Oncology, 2020 - karger.com
Abstract Interleukin-6 (IL-6) is a member of the pro-inflammatory cytokine family, induces the
expression of a variety of proteins responsible for acute inflammation, and plays an …

Hitting a complex target: an update on interleukin-6 trans-signalling

GH Waetzig, S Rose-John - Expert opinion on therapeutic targets, 2012 - Taylor & Francis
Introduction: Interleukin-6 (IL-6) is a key target in inflammation and cancer. Selective
inhibition of IL-6 trans-signalling could provide the same or even higher therapeutic efficacy …

[HTML][HTML] Function and proteolytic generation of the soluble interleukin-6 receptor in health and disease

T Schumertl, J Lokau, S Rose-John… - Biochimica et Biophysica …, 2022 - Elsevier
The pleiotropic cytokine interleukin-6 (IL-6) is involved in numerous physiological and
pathophysiological functions that include development, immune cell differentiation …