IL-6 activates various cell types carrying the membrane bound IL-6R (classical IL-6
signaling) as well as IL-6R− gp130+ cells via the soluble IL-6R (IL-6 trans-signaling). IL-6 …

Interleukin (IL)-6 is a pro-inflammatory cytokine that produces multifunctional effects.
Deregulated IL-6 production and signaling are associated with chronic inflammatory …

IL-6 plays a pivotal role in immune responses and certain oncologic conditions. The intense
investigation of its biological activity and function led to the discovery of two different IL-6 …

Background: IL-6, a glycoprotein composed of 212 amino acids in human, has a wide range
of biological activity, including regulation of immune response, support of hematopoiesis …

Abstract Interleukin-6 (IL-6) is a multifunctional cytokine with well-defined pro-and anti-
inflammatory properties. Although only small amounts in the picogram range can be …

Abstract Interleukin-6 (IL-6) is a pleiotropic cytokine with significant functions in the
regulation of the immune system. As a potent pro-inflammatory cytokine, IL-6 plays a pivotal …

Interleukin-6 (IL-6) is a pleiotropic cytokine with roles in immunity, tissue regeneration, and
metabolism. Rapid production of IL-6 contributes to host defense during infection and tissue …

Interleukin-6 (IL-6) is a pleiotropic cytokine that activates a classic signalling pathway upon
binding to its membrane-bound receptor (IL-6R). Alternatively, IL-6 may 'trans-signal'in a …

Abstract Interleukin (IL)-6, a cytokine featuring redundancy and pleiotropic activity,
contributes to host defense against acute environmental stress, while dysregulated …

Soluble cytokine receptors are frequently found in human serum, most of them possessing
antagonistic properties. The Interleukin 6 receptor (IL-6R) is found as a transmembrane …