Interleukin-6: from basic biology to selective blockade of pro-inflammatory activities

J Scheller, C Garbers, S Rose-John - Seminars in immunology, 2014 - Elsevier
Cytokines receptors exist in membrane bound and soluble form. A soluble form of the
human IL-6R is generated by limited proteolysis and alternative splicing. The complex of IL …

Interleukin-6 and interleukin-11: same same but different

C Garbers, J Scheller - Biological chemistry, 2013 - degruyter.com
The pleiotropic physiological functions of interleukin (IL-) 6 type cytokines range from
embryonic development and tissue homoeostasis to neuronal development and T cell …

Interleukin-4 receptor signaling and its binding mechanism: A therapeutic insight from inhibitors tool box

Z Ul-Haq, S Naz, MA Mesaik - Cytokine & growth factor reviews, 2016 - Elsevier
Abstract Studies on Interlukin-4 (IL-4) disclosed great deal of information about its various
physiological and pathological roles. All these roles depend upon its interaction and …

Updating interleukin‐6 classic‐and trans‐signaling

J Scheller, J Grötzinger, S Rose‐John - Signal Transduction, 2006 - Wiley Online Library
The cytokine interleukin‐6 has been identified and cloned among others as B‐cell
stimulatory factor, hepatocyte stimulating factor, plasmacytoma growth factor, and interferon …

Interleukin‐6: Structure‐function relationships

RJ Simpson, A Hammacher, DK Smith… - Protein …, 1997 - Wiley Online Library
Abstract Interleukin‐6 (IL‐6) is a multifunctional cytokine that plays a central role in host
defense due to its wide range of immune and hematopoietic activities and its potent ability to …

IL-6 receptor and mechanism of signal transduction

T Kishimoto, S Akira, T Taga - International journal of …, 1992 - Elsevier
Abstract Interleukin-6 (IL-6) is a multifunctional cytokine which acts on a wide variety of cells,
exerting growth promotion, growth inhibition, or specific gene expression including cellular …

Inhibition of IL-6 for the treatment of inflammatory diseases

N Nishimoto, T Kishimoto - Current opinion in pharmacology, 2004 - Elsevier
Interleukin-6 (IL-6) is a pleiotropic cytokine with various biological activities. Deregulated
overproduction of IL-6 has been found to play pathological roles in chronic inflammatory …

Targeting IL-10 family cytokines for the treatment of human diseases

X Wang, K Wong, W Ouyang… - Cold Spring Harbor …, 2019 - cshperspectives.cshlp.org
Members of the interleukin (IL)-10 family of cytokines play important roles in regulating
immune responses during host defense but also in autoimmune disorders, inflammatory …

[HTML][HTML] Structural understanding of interleukin 6 family cytokine signaling and targeted therapies: focus on interleukin 11

RD Metcalfe, TL Putoczki, MDW Griffin - Frontiers in immunology, 2020 - frontiersin.org
Cytokines are small signaling proteins that have central roles in inflammation and cell
survival. In the half-century since the discovery of the first cytokines, the interferons, over fifty …

[HTML][HTML] Proteolytic control of Interleukin-11 and Interleukin-6 biology

J Lokau, M Agthe, CM Flynn, C Garbers - Biochimica et Biophysica Acta …, 2017 - Elsevier
Abstract Interleukin-11 (IL-11) and IL-6 are secreted glycoproteins which fulfill important
homeostatic functions. Activation of target cells occurs via membrane-bound IL-11 and IL-6 …