Ten years have passed since the molecular cloning of interleukin 6 (IL-6) in 1986. IL-6 is a
typical cytokine, exhibiting functional pleiotropy and redundancy. IL-6 is involved in the …

IL-6 signaling plays a prominent role in tumorigenesis and metastasis. In this review we
discuss the recent evidence describing the tumor intrinsic and extrinsic functions of this …

Cytokine-targeted therapy has generated a paradigm shift in the treatment of several
immune-mediated diseases. Interleukin-6 (IL-6), which was initially identified as B-cell …

Interleukin-6 (IL-6) plays an important role in the neoplastic process through its action on
cancer cell adhesion, motility, proliferation, tumor-specific antigen expression, and …

IL-6 is a pleiotropic cytokine involved in many biological functions that affect tissues beyond
the immune system and the vasculature. This multifunctional cytokine exerts its actions via …

IL-2 was initially characterized as a T cell growth factor in the 1970s, and has been studied
intensively ever since. Decades of research have revealed multiple and diverse roles for this …

Abstract Interleukin 6 (IL-6) has a broad effect on cells of the immune system and those not
of the immune system and often displays hormone-like characteristics that affect homeostatic …

Regulatory T cells (Treg) play a crucial role in maintaining immune homeostasis since Treg
dysfunction in both animals and humans is associated with multi-organ autoimmune and …

Interleukin-2 (IL-2) is a pleiotropic cytokine produced after antigen activation that plays
pivotal roles in the immune response. Discovered as a T cell growth factor, IL-2 additionally …

Abstract Interleukin-6 (IL-6) is a prototypical cytokine with functional pleiotropy and plays an
important role in host defense. When infections or tissue injuries occur, IL-6 is promptly …