Interleukin 6 (IL-6), a pleiotropic protein of about 26 kDa molecular weight, plays a role in
diverse organ systems. These activities range from such proinflammatory activities as …

Interleukin‐8 has long been recognized to have anti‐inflammatory activity, which has been
established in various models of infection, inflammation, and cancer. Several cell types …

IL-1O (interleukin-10) negatively regulates inflammation through a mechanism that blocks
the expression of pro-inflammatory genes encoding cytokines, chemokines, cell-surface …

IL-6 trans-signaling via the soluble IL-6 receptor (sIL-6R) plays a critical role in chronic
inflammation and cancer. Soluble gp130 (sgp130) specifically inhibits IL-6 trans-signaling …

Review on three IL-4-related branch points for immune regulation: alternative splicing of IL-
4, differential receptor engagement, and differential regulation of macrophage activation by …

Interleukin 10 is a cytokine with the ability to reduce or terminate inflammation. Chronic viral
infection, such as infection of chronic hepatitis B, hepatitis C and HIV, has increased levels …

Interleukin-6 is a cytokine involved in the regulation of the immune system and the central
nervous system. Interleukin-6 binds to an interleukin-6 receptor, and then associates with a …

The use of cytokines from the IL-2 family (also called the common γ chain cytokine family)
such as interleukin (IL)-2, IL-7, IL-15, and IL-21 to activate the immune system of cancer …

Cytokines are secreted or membrane-presented molecules that mediate broad cellular
functions, including development, differentiation, growth and survival. Accordingly, the …

Interleukin (IL)-10 performs an irreplaceable role in negatively regulating inflammation,
primarily through a mechanism that selectively blocks the expression of pro-inflammatory …