Objectives As morbidly obese patients are prone to surgical site infections, adequate blood
and subcutaneous tissue concentrations of prophylactic antibiotic agents during surgery are …

Traditionally, there have been uniform antibiotic dosing guidelines for prophylaxis for clean–
clean-contaminated surgery in both non-obese and obese adults. All other factors …

Background: Cefazolin is used commonly to prevent surgical site infection (SSI) after
operations on patients with morbid obesity (MO), but specific dosing guidelines are lacking …

Purpose The goal of this pharmacokinetic (PK) study was to evaluate whether a single 2-g
prophylactic dose of cefazolin given (IV) bolus provides effective protective cefazolin levels …

Background Most surgical prophylaxis guidelines recommend a 3-g cefazolin intravenous
dose in patients weighing≥ 120 kg. However, this recommendation is primarily based on …

Purpose The aim of this study was to assess the pharmacokinetics and protein binding of
cefazolin in morbidly obese patients undergoing bariatric surgery, to study the influence of …

Objectives The objective of this study was to describe the population pharmacokinetics of
cefazolin in plasma and the interstitial fluid of subcutaneous tissue of post-trauma critically ill …

BACKGROUND: Obesity is a significant risk factor for surgical site infections (SSIs), for
poorly understood reasons. SSIs are a major cause of morbidity, prolonged hospitalization …

Background: Patients undergoing cesarean delivery typically receive a 1-g to 2-g dose of
cefazolin as pre-operative antibacterial prophylaxis. This traditional dosage may not provide …

OBJECTIVE: To estimate the adequacy of antimicrobial activity of preoperative antibiotics at
the time of cesarean delivery as a function of maternal obesity. METHODS: Twenty-nine …