Emergence of epidemic clones and antibiotic resistance development compromises the
management of Pseudomonas aeruginosa cystic fibrosis (CF) chronic respiratory infections …

Chronic respiratory infection by Pseudomonas aeruginosa is a major cause of mortality in
cystic fibrosis (CF). We investigated the interplay between three key microbiological aspects …

Pseudomonas aeruginosa is an important opportunistic pathogen, especially in the context
of infections of cystic fibrosis (CF). In order to facilitate coordinated study of this pathogen, an …

The advent of high-throughput sequencing techniques has made it possible to follow the
genomic evolution of pathogenic bacteria by comparing longitudinally collected bacteria …

Pseudomonas aeruginosa exploits intrinsic and acquired resistance mechanisms to resist
almost every antibiotic used in chemotherapy. Antimicrobial resistance in P. aeruginosa …

Abstract Background Chronic infection with Pseudomonas aeruginosa is a major cause of
morbidity and mortality in cystic fibrosis (CF) patients, and a more complete understanding of …

During the chronic lung infection of patients with cystic fibrosis (CF), Pseudomonas
aeruginosa can survive for long periods due to adaptive evolution mediated by genetic …

Background: During its persistence in cystic fibrosis (CF) airways, P. aeruginosa develops a
series of phenotypic changes by the accumulation of pathoadaptive mutations. A better …

One of the most striking features of Pseudomonas aeruginosa is its outstanding capacity for
developing antimicrobial resistance to nearly all available antipseudomonal agents through …

Intense genome sequencing of Pseudomonas aeruginosa isolates from cystic fibrosis (CF)
airways has shown inefficient eradication of the infecting bacteria, as well as previously …