A key feature of malignant cells is their capacity to invade surrounding tissue and
metastasize to distant sites (1, 2). The process of metastasis involves a complex series of …

To date, cancer is still the second most prevalent cause of death after cardiovascular
diseases in the industrialized word, whereby the primary cause of cancer is not attributed to …

Metastasis requires tumor cell dissemination to different organs from the primary tumor.
Dissemination is a complex cell motility phenomenon that requires the molecular …

More than 90% of all cancer deaths are directly related to metastasis. Transit of cells through
the microcirculation is one of the key features of metastasis. It is not clear whether cancer …

PURPOSE: The interactions of blood-borne colorectal carcinoma cells with vascular
endothelium are important during hematogenous formation of distant metastases. To adhere …

The clinical course–and hence the prognosis–of patients suffering from malignant tumors
are essentially determined by the capability of tumor cells to metastasize. During the past …

Simple Summary Cell migration is an essential process from embryogenesis to cell death.
This is tightly regulated by numerous proteins that help in proper functioning of the cell. In …

Metastasis, the process by which cancer cells leave the primary tumour, disseminate and
form secondary tumours at anatomically distant sites, is a serious clinical problem as it is …

In this review, the role of extracellular factors in the stimulation and regulation of tumor cell
motility are discussed. Tumor cells respond in a motile fashion to a variety of external …

It has become evident that mechanical forces play a key role in cancer metastasis, a
complex series of steps that is responsible for the majority of cancer-related deaths. One …