Upon activation, naïve CD4+ T helper (Th) cells differentiate into distinct Th effector cell
lineages depending on the local cytokine environment. However, these polarized Th cells …

Naïve CD4+ helper T (TH) cells, upon activation by antigen‐presenting cells (APC),
differentiate into different types of effector cells that are characterized by their distinct …

Abstract OTHER ARTICLES PUBLISHED IN THIS MINI-REVIEW SERIES ON Th17 CELLS
Induction of interleukin-17 production by regulatory T cells. Clin Exp Immunol 2009; doi …

Since the original identification of the T helper 17 (Th17) subset in 2005, it has become
evident that these cells do not only contribute to host defence against pathogens, such as …

CD4+ T helper cells are classical but constantly reinterpreted T-cell subset, playing critical
roles in a diverse range of inflammatory responses or diseases. Depending on the cytokines …

T helper (TH) cells can assume different phenotypes characterized by the secretion of
distinct effector molecules. Interferon-γ producing TH1 and IL-4 producing TH2 cells have …

Th17 cells have been shown to be strong inducers of tissue inflammation and autoimmune
diseases. However, not all Th17 cells are pathogenic and increasing data suggest that Th17 …

Extensive cellular heterogeneity exists within specific immune-cell subtypes classified as a
single lineage, but its molecular underpinnings are rarely characterized at a genomic scale …

Upon activation, naive CD4+ T cells differentiate into different lineages of effector Th
subsets. Each subset is characterized by its unique cytokine profile and biological functions …

Th17 cells are a subset of CD4+ effector T cells characterized by expression of the IL-17-
family cytokines, IL-17A and IL-17F. Since their discovery nearly a decade ago, Th17 cells …