Recently, a paradigm shift has emerged in T-cell-mediated adaptive immunity. On the heels
of the discovery of T cells with immunosuppressive function, so-called regulatory T cells …

Th17 cells are an effector lineage of CD4 T cells that can contribute to protection against
microbial pathogens and to the development of harmful autoimmune and inflammatory …

T helper (Th) 17 cells have been proposed to represent a new CD4+ T cell lineage that is
important for host defense against fungi and extracellular bacteria, and the development of …

Abstract Interleukin 17 (IL-17)-producing helper T cells (TH17 cells) have been broadly
linked to the pathogenesis of multiple autoimmune diseases. In the few short years since the …

Upon activation, naive CD4+ T cells differentiate into effector Th cell subsets. The stability
and plasticity of effector Th cells have not been well understood. In this study we used an IL …

Abstract T helper 17 (Th17) cells represent a new subset of CD4+ effector T cells which have
been described in both mice and humans. However, some differences seem to exist …

Naive CD4+ cells differentiate into T helper (Th1, Th2, Th9, Th17) and regulatory T (Treg)
cells to execute their immunologic function. Whereas TGF-β suppresses Th1 and Th2 cell …

This review focuses on the biology of T helper 17 (Th17) and regulatory T (Treg) cells and
their role in inflammatory diseases, such as rheumatoid arthritis. Th17 cells represent a pro …

Given the association with autoimmune disease, there is great interest in defining cellular
factors that limit overactive or misdirected Th17-type inflammation. Using in vivo and in vitro …

Over the last decade, our understanding of helper/effector T cell differentiation has changed
dramatically. The discovery of interleukin (IL-) 17-producing T cells (Th17) and other subsets …