In this report, we investigate the role of the RNA-binding protein HuR during skeletal
myogenesis. At the onset of myogenesis in differentiating C2C12 myocytes and in vivo in …

The formation of muscle fibers involves the sequential expression of many proteins that
regulate key steps during myoblast-to-myotube transition. MyoD, myogenin, and the cyclin …

Although the function of posttranscriptional processes in regulating the expression of genes
involved in muscle fiber formation (myogenesis) is well accepted, the mechanisms by which …

Muscle fiber formation requires the sequential expression of myogenic regulatory factors
(MRFs) such as MyoD and myogenin. The messenger RNAs encoding these two proteins …

In dividing cells, the RNA-binding protein HuR associates with and stabilizes labile mRNAs
encoding proliferative proteins, events that are linked to the increased cytoplasmic presence …

The master posttranscriptional regulator HuR promotes muscle fiber formation in cultured
muscle cells. However, its impact on muscle physiology and function in vivo is still unclear …

The muscle-specific long noncoding RNA linc-MD1 was shown to be expressed during early
phases of muscle differentiation and to trigger the switch to later stages by acting as a …

HuR promotes myogenesis by stabilizing the MyoD, myogenin and p21 mRNAs during the
fusion of muscle cells to form myotubes. Here we show that HuR, via a novel mRNA …

In a breast tumor xenograft model, the MCT-1 oncogene increases the in vivo tumorgenicity
of MCF7 cells by promoting angiogenesis and inhibiting apoptosis. Increases in the tumor …

Gene expression is potently regulated through the action of RNA-binding proteins (RBPs)
and microRNAs (miRNAs). Here, we present evidence of a miRNA regulating an RBP. The …