This paper reviews the general mechanisms by which leptin acts as a regulator of lipid
reserves through changes in food intake, energy expenditure and fuel selection, with an …

Leptin is hypothesized to function as a negative feedback signal in the regulation of energy
balance. It is produced primarily by adipose tissue and circulating concentrations correlate …

Since the discovery of leptin in 1994, a considerable amount of research has focused on
leptin as a central regulator of body weight. In the animal model, research has demonstrated …

Leptin, a peptide hormone (167 aa) mainly expressed in adipocytes, and its hypothalamic
receptors are integral components of a complex physiological system evolved to regulate …

Leptin is an adipocyte hormone involved in the regulation of energy homeostasis. Generally
accepted biological effects of leptin are inhibition of food intake and stimulation of metabolic …

In recent years, the adipose tissue has emerged as an important endocrine organ. It is now
recognized that besides storing energy the adipocytes also secrete several bioactive …

Obesity results from an abnormal accumulation of fat in the white adipose tissue. Recent
research utilizing genetic models of obesity in rodents has implicated a major role of leptin …

Leptin has received considerable attention as a newly recognized metabolic hormone and
for its potential for therapeutic use in the treatment of human obesity. Furthermore, defects in …

BACKGROUND: Leptin is an adipose protein regulating food intake in the hypothalamus.
Animal studies have suggested that leptin also acts in an auto-/paracrine fashion on adipose …

Leptin has been shown to reduce body fat in vivo. Adipocytes express the leptin receptor;
therefore, it is realistic to expect a direct effect of leptin on adipocyte growth and metabolism …