According to the World Health Organization, infertility affects up to 14% of couples under
reproductive age, leading to an exponential rise in the use of assisted reproduction as a …

The survival of the preimplantation mammalian embryo depends not only on providing the
proper conditions for normal development but also on acquiring the mechanisms by which …

Heat shock compromises development of preimplantation bovine embryos and the
percentage of blastomeres labeled as TUNEL-positive. It was hypothesized that TUNEL …

Background The causes, modes, biological role and prospective significance of cell death in
preimplantation development in humans and other mammals are still poorly understood …

Mammalian development involves an exquisite choreography of cell division, differentiation,
locomotion, programmed cell death, and senescence that directs the transformation of a …

The postimplantation developmental potential of embryos can be affected by various forms
of cell death, such as apoptosis, at preimplantation stages. However, correct assessment of …

In this study we investigated chronological onset and involvement of active caspase‐3,
apoptotic nuclear morphology, and TUNEL‐labeling, as well as ultrastructural evidence of …

Female and male embryos show differences in gene expression and metabolism from the
onset of their genome. Those differences are affected by environmental factors. The …

Developmental senescence is a form of programmed senescence that contributes to
morphogenesis during embryonic development. We showed recently that the SIX1 …

Cell death occurs during early development in vivo and in vitro, although little is known
about the mechanism of blastomere death and the relation to embryonic loss. Apoptosis …