Endothelin is a potent vasoconstrictor, whereas endothelium-derived relaxing factor (EDRF)
is a potent vasodilator. Both are produced by the endothelium. Although they have been …

Endothelin-1 is a 21-amino acid endothelial vasoconstrictor peptide that may be the
physiological antagonist of endothelium-derived relaxing factor (EDRF). Endothelin-1 (10 …

In addition to preserving the permselectivity of the vascular wall and providing an
antithrombogenic surface, the vascular endothelium contributes importantly to the regulation …

We review below published studies of endothelium-dependent vasodilation in vivo.
Endothelium-dependent vasodilation has been demonstrated in conduit arteries in vivo and …

Removal of venous endothelium in man leads to vasoconstriction and loss of dilator
response to acetylcholine but not to glyceryl trinitrate. This pattern of responses can be …

This chapter reviews evidence that the endothelium-derived relaxing factor (EDRF)
described by Furchgott and Zawadzki (1980) is released spontaneously and is active …

We have previously shown that porcine endothelin (ET-1) releases endothelium-derived
relaxing factor (EDRF) in the rat isolated perfused mesentery. Here we show that both ET-1 …

It has been suggested that endothelin (ET) induces the release of endothelium-derived
relaxing factor (EDRF). To explore the possible modification of ET-1nduced renal …

Aortic rings from SHR are reported lo have a decreased relaxation response to the
endothelium-dependent agent acetylcholine compared with rings from WKY rats. Thus, a …

A large number and variety of compounds (acetylcholine, adenosine diphosphate,
adenosine triphosphate, arachidonic acid, bradykinin, Ca2+ ionophores, calcitonin gene …