The production of β-lactamases is a prevalent mechanism that poses serious pressure on
the control of bacterial resistance. Furthermore, the unavoidable and alarming increase in …

ABSTRACT OXA-48-type β-lactamases are now routinely encountered in bacterial infections
caused by carbapenem-resistant Enterobacterales. These enzymes are of high and growing …

Modern medicine is threatened by the rising tide of antimicrobial resistance, especially
among Gram-negative bacteria, where resistance to β-lactams is most often mediated by β …

The extended-spectrum β-lactamases have evolved owing to the extensive use of the
oxyimino-cephalosporins, and have greatly reduced the treatment options for serious …

Abstract OXA-48-type ß-lactamases are the most prevalent carbapenemase-type in
Enterobacterales in Switzerland, predominantly found in Escherichia coli and Klebsiella …

Resistance to antipseudomonal penicillins and cephalosporins is often driven by the
overproduction of the intrinsic β-lactamase AmpC. However, OXA-10-family β-lactamases …

ESKAPE pathogens are the leading cause of nosocomial infections. The Global Priority List
of WHO has categorized ESKAPE as priority 1 and 2 pathogens. Even though several …

Carbapenem-hydrolyzing class D β-lactamases (CHDLs) are enzymes of the utmost clinical
importance due to their ability to produce resistance to carbapenems, the antibiotics of last …

OXA-48-producing Enterobacterales have now widely disseminated globally. A sign of their
extensive spread is the identification of an increasing number of OXA-48 variants. Among …

Two extended-spectrum mutants of the class D β-lactamase OXA-10 (PSE-2) from
Pseudomonas aeruginosa isolates obtained in Ankara, Turkey, were described previously …