Objective We investigated the frequency of β-amyloid (Aβ) positivity in 9 groups classified
according to a combination of 3 different cognition states and 3 distinct levels of white matter …

Importance It remains unclear if and how associations between cerebral small-vessel
disease and Alzheimer disease (AD) pathology lead to cognitive decline and dementia …

Background: We estimated the prevalence and incidence of amyloid-β deposition (A), small-
vessel disease (V), and neurodegeneration (N) biomarker positivity in community-dwelling …

Objective: We investigated the relation of circulating plasma β-amyloid (Aβ) with MRI
markers of small vessel disease (SVD) in dementia-free community persons. Methods …

Background: Alzheimer's disease (AD) frequently co-occurs with other brain pathologies.
Recent studies suggest there may be a mechanistic link between AD and small vessel …

Background Both cerebral amyloid angiopathy (CAA) and hypertensive arteriopathy (HA)
are related to cognitive impairment and dementia. This study aimed to clarify CAA-and HA …

Background Secondary prevention clinical trials for Alzheimer's disease (AD) target amyloid
accumulation in asymptomatic, amyloid-positive individuals, but it is unclear to what extent …

Background Cerebrovascular disease (CVD) and amyloid-β (Aβ) often coexist, but their
influence on neurodegeneration and cognition in predementia stages remains unclear. We …

Background: Plasma amyloid-ß (Aß) levels are increasingly studied as a potential,
accessible marker of cognitive impairment and dementia. The most common plasma Aß …

Background There is controversy concerning whether Alzheimer's disease (AD) with early
onset is distinct from AD with late onset with regard to amyloid pathology and neuronal …