Amyloid-β (Aβ) and cerebral small vessel disease (CSVD) commonly coexist. They can
occur independently by chance, or may interact with each other. We aimed to determine …

Background: Current studies suggest an interaction between vascular mechanisms and
neurodegenerative processes that leads to late-onset Alzheimer disease (AD). We tested …

Background Improved understanding is needed of risk factors and markers of disease
progression in preclinical Alzheimer's disease. We assessed associations between brain β …

It remains unclear to what extent cerebrovascular burden relates to amyloid beta (Aβ)
deposition, neurodegeneration, and cognitive dysfunction in mixed disease populations with …

Objective To assess the interactions among three types of pathology (ie, cerebrovascular
disease, hippocampal sclerosis [HS], and Alzheimer's disease [AD]), cognitive status, and …

Background and Purpose—Some studies have reported associations between intracranial
atherosclerosis and Alzheimer disease pathology. We aimed to correlate severity of cerebral …

Background Cerebral small vessel disease (CSVD) comprises a variety of disorders
affecting small arteries and microvessels of the brain, manifesting as white matter …

Lacunar brain infarcts and cerebral white matter lesions are frequently observed on
magnetic resonance imaging scans in elderly subjects. These lesions are also frequent in …

Objective Extensive cortical β-amyloid (Aβ positivity) has been linked to cognitive decline,
but the clinical significance of elevations in Aβ within the negative range is unknown …

Objective To determine whether vascular risk and Alzheimer disease (AD) biomarkers have
independent or synergistic effects on cognitive decline and whether vascular risk is …