Alzheimer's disease (AD) is traditionally thought of as a neurodegenerative disease. Recent
evidence shows that beta amyloid-independent vascular changes and beta amyloid …

In cognitively normal (CN) elderly individuals, white matter hyperintensities (WMH) are
commonly viewed as a marker of cerebral small vessel disease (SVD). SVD is due to …

Importance Cerebrovascular disease (CVD) and Alzheimer disease are significant causes of
cognitive impairment in the elderly. However, few studies have evaluated the relationship …

Background and Purpose This study investigated the contribution of white-matter
hyperintensities (WMH) and lacunar infarcts (LI) to the risk of Alzheimer's disease (AD) in an …

Objectives: We sought to identify demographic and clinical features that were associated
with expression of symptoms in the presence of Alzheimer disease (AD) neuropathologic …

BACKGROUND: Vascular risk factors increase the risk of Alzheimer's disease (AD). The
mechanisms for these associations are unclear, and may be due to misdiagnosis of a …

Objective: Cerebral amyloid angiopathy (CAA) is a common age-related small vessel
disease (SVD). Patients without intracerebral hemorrhage (ICH) typically present with …

Background and objectives Vascular risk factors and elevated β-amyloid (Aβ) are commonly
observed together among older adults. Here, we examined the interactive vs independent …

Previous work examining Alzheimer's Disease Neuroimaging Initiative (ADNI) normal
controls using cluster analysis identified a subgroup characterized by substantial brain …

Background and Purpose—Although the association between cerebral amyloid angiopathy
(CAA) and cognitive impairment is increasingly recognized, it is not clear whether this is …