[图书][B] Impact of Genetic Variation in the Endocannabinoid-Degrading Enzyme FAAH on Dopamine D2/3 Receptor Status: Neuroimaging Studies in Human and Mice …

E Mansouri - 2020 - search.proquest.com
BACKGROUND: The endocannabinoid and dopaminergic systems have independently
been implicated in addiction. We investigated a potential interaction between a genetically …

D3 dopamine receptors and a missense mutation of fatty acid amide hydrolase linked in mouse and men: implication for addiction

E Mansouri, JN Nobrega, MN Hill, RF Tyndale… - …, 2020 - nature.com
The endocannabinoid and dopaminergic systems have independently been implicated in
substance use disorder and obesity. We investigated a potential interaction between …

S265. Endocannabinoid Metabolism and Alcohol Consumption in Youth: A PET Study With the Fatty Acid Amide Hydrolase Radioligand [11C] CURB

LM Best, CS Hendershot… - Biological …, 2018 - biologicalpsychiatryjournal.com
Background Fatty acid amide hydrolase (FAAH) regulates endocannabinoid tone through
degradation of anandamide, a major endocannabinoid neurotransmitter. In humans, FAAH …

The Fatty Acid Amide Hydrolase C385A Variant Affects Brain Binding of the Positron Emission Tomography Tracer [11C]CURB

I Boileau, RF Tyndale, B Williams… - Journal of Cerebral …, 2015 - journals.sagepub.com
The common functional single-nucleotide polymorphism (rs324420, C385A) of the
endocannabinoid inactivating enzyme fatty acid amide hydrolase (FAAH) has been …

Severity of alcohol dependence is associated with the fatty acid amide hydrolase Pro129Thr missense variant

ME Sloan, JL Gowin, J Yan, ML Schwandt… - Addiction …, 2018 - Wiley Online Library
The endocannabinoid system plays an important role in reward and addiction. One of the
two main endocannabinoid neurotransmitters, anandamide, is metabolized by fatty acid …

Fatty acid amide hydrolase binding in brain of cannabis users: imaging with the novel radiotracer [11C] CURB

I Boileau, E Mansouri, B Williams, B Le Foll, P Rusjan… - Biological …, 2016 - Elsevier
Background One of the major mechanisms for terminating the actions of the
endocannabinoid anandamide is hydrolysis by fatty acid amide hydrolase (FAAH), and …

Lower brain fatty acid amide hydrolase in treatment-seeking patients with alcohol use disorder: a positron emission tomography study with [C-11] CURB

LM Best, B Williams, B Le Foll, E Mansouri… - …, 2020 - nature.com
The endocannabinoid enzyme, fatty acid amide hydrolase (FAAH), has been proposed as a
therapeutic target for alcohol use disorder (AUD) and co-morbid psychiatric illnesses …

A nonsynonymous polymorphism in the human fatty acid amide hydrolase gene did not associate with either methamphetamine dependence or schizophrenia

Y Morita, H Ujike, Y Tanaka, N Uchida, A Nomura… - Neuroscience …, 2005 - Elsevier
Genetic contributions to the etiology of substance abuse and dependence are topics of
major interest. Acute and chronic cannabis use can produce drug-induced psychosis …

386. Fatty Acid Amide Hydrolase is Associated With Impulsiveness: A Pet Study in Overnight Abstinent Chronic Cannabis Users

C Poluga, M Querido, N Boachie… - Biological …, 2023 - biologicalpsychiatryjournal.com
Background Fatty Acid Amide Hydrolase (FAAH) is the enzyme responsible for metabolizing
the major endocannabinoid anandamide. FAAH has been linked with addiction-relevant …

Involvement of Endocannabinoids in Alcohol “Binge” Drinking: Studies of Mice with Human Fatty Acid Amide Hydrolase Genetic Variation and After CB 1 Receptor …

Y Zhou, T Huang, F Lee… - Alcoholism: Clinical and …, 2016 - Wiley Online Library
Background The endocannabinoid system has been found to play an important role in
modulating alcohol intake. Inhibition or genetic deletion of fatty acid amide hydrolase (FAAH; …