[图书][B] Impact of Genetic Variation in the Endocannabinoid-Degrading Enzyme FAAH on Dopamine D2/3 Receptor Status: Neuroimaging Studies in Human and Mice …
E Mansouri - 2020 - search.proquest.com
BACKGROUND: The endocannabinoid and dopaminergic systems have independently
been implicated in addiction. We investigated a potential interaction between a genetically …
been implicated in addiction. We investigated a potential interaction between a genetically …
D3 dopamine receptors and a missense mutation of fatty acid amide hydrolase linked in mouse and men: implication for addiction
E Mansouri, JN Nobrega, MN Hill, RF Tyndale… - …, 2020 - nature.com
The endocannabinoid and dopaminergic systems have independently been implicated in
substance use disorder and obesity. We investigated a potential interaction between …
substance use disorder and obesity. We investigated a potential interaction between …
S265. Endocannabinoid Metabolism and Alcohol Consumption in Youth: A PET Study With the Fatty Acid Amide Hydrolase Radioligand [11C] CURB
LM Best, CS Hendershot… - Biological …, 2018 - biologicalpsychiatryjournal.com
Background Fatty acid amide hydrolase (FAAH) regulates endocannabinoid tone through
degradation of anandamide, a major endocannabinoid neurotransmitter. In humans, FAAH …
degradation of anandamide, a major endocannabinoid neurotransmitter. In humans, FAAH …
The Fatty Acid Amide Hydrolase C385A Variant Affects Brain Binding of the Positron Emission Tomography Tracer [11C]CURB
I Boileau, RF Tyndale, B Williams… - Journal of Cerebral …, 2015 - journals.sagepub.com
The common functional single-nucleotide polymorphism (rs324420, C385A) of the
endocannabinoid inactivating enzyme fatty acid amide hydrolase (FAAH) has been …
endocannabinoid inactivating enzyme fatty acid amide hydrolase (FAAH) has been …
Severity of alcohol dependence is associated with the fatty acid amide hydrolase Pro129Thr missense variant
The endocannabinoid system plays an important role in reward and addiction. One of the
two main endocannabinoid neurotransmitters, anandamide, is metabolized by fatty acid …
two main endocannabinoid neurotransmitters, anandamide, is metabolized by fatty acid …
Fatty acid amide hydrolase binding in brain of cannabis users: imaging with the novel radiotracer [11C] CURB
Background One of the major mechanisms for terminating the actions of the
endocannabinoid anandamide is hydrolysis by fatty acid amide hydrolase (FAAH), and …
endocannabinoid anandamide is hydrolysis by fatty acid amide hydrolase (FAAH), and …
Lower brain fatty acid amide hydrolase in treatment-seeking patients with alcohol use disorder: a positron emission tomography study with [C-11] CURB
LM Best, B Williams, B Le Foll, E Mansouri… - …, 2020 - nature.com
The endocannabinoid enzyme, fatty acid amide hydrolase (FAAH), has been proposed as a
therapeutic target for alcohol use disorder (AUD) and co-morbid psychiatric illnesses …
therapeutic target for alcohol use disorder (AUD) and co-morbid psychiatric illnesses …
A nonsynonymous polymorphism in the human fatty acid amide hydrolase gene did not associate with either methamphetamine dependence or schizophrenia
Y Morita, H Ujike, Y Tanaka, N Uchida, A Nomura… - Neuroscience …, 2005 - Elsevier
Genetic contributions to the etiology of substance abuse and dependence are topics of
major interest. Acute and chronic cannabis use can produce drug-induced psychosis …
major interest. Acute and chronic cannabis use can produce drug-induced psychosis …
386. Fatty Acid Amide Hydrolase is Associated With Impulsiveness: A Pet Study in Overnight Abstinent Chronic Cannabis Users
C Poluga, M Querido, N Boachie… - Biological …, 2023 - biologicalpsychiatryjournal.com
Background Fatty Acid Amide Hydrolase (FAAH) is the enzyme responsible for metabolizing
the major endocannabinoid anandamide. FAAH has been linked with addiction-relevant …
the major endocannabinoid anandamide. FAAH has been linked with addiction-relevant …
Involvement of Endocannabinoids in Alcohol “Binge” Drinking: Studies of Mice with Human Fatty Acid Amide Hydrolase Genetic Variation and After CB 1 Receptor …
Y Zhou, T Huang, F Lee… - Alcoholism: Clinical and …, 2016 - Wiley Online Library
Background The endocannabinoid system has been found to play an important role in
modulating alcohol intake. Inhibition or genetic deletion of fatty acid amide hydrolase (FAAH; …
modulating alcohol intake. Inhibition or genetic deletion of fatty acid amide hydrolase (FAAH; …
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- human and mice receptor status
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- genetic variation implications for addictions
- missense mutation implication for addiction
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