Requirement of Cholesterol for Calcium‐Dependent Vesicle Fusion by Strengthening Synaptotagmin‐1‐Induced Membrane Bending
Cholesterol is essential for neuronal activity and function. Cholesterol depletion in the
plasma membrane impairs synaptic transmission. However, the molecular mechanisms by …
plasma membrane impairs synaptic transmission. However, the molecular mechanisms by …
Synaptotagmin-7 outperforms synaptotagmin-1 to promote the formation of large, stable fusion pores via robust membrane penetration
Abstract Synaptotagmin-1 and synaptotagmin-7 are two prominent calcium sensors that
regulate exocytosis in neuronal and neuroendocrine cells. Upon binding calcium, both …
regulate exocytosis in neuronal and neuroendocrine cells. Upon binding calcium, both …
Synaptotagmin activates membrane fusion through a Ca2+-dependent trans interaction with phospholipids
A Stein, A Radhakrishnan, D Riedel… - Nature structural & …, 2007 - nature.com
Synaptotagmin-1 is the calcium sensor for neuronal exocytosis, but the mechanism by which
it triggers membrane fusion is not fully understood. Here we show that synaptotagmin …
it triggers membrane fusion is not fully understood. Here we show that synaptotagmin …
[HTML][HTML] Productive and Non-productive Pathways for Synaptotagmin 1 to Support Ca2+-Triggered Fast Exocytosis
J Kim, YK Shin - Frontiers in Molecular Neuroscience, 2017 - frontiersin.org
Ca2+-triggered SNARE-mediated membrane fusion is essential for neuronal
communication. The speed of this process is of particular importance because it sets a time …
communication. The speed of this process is of particular importance because it sets a time …
[PDF][PDF] Single vesicle assaying of SNARE-synaptotagmin-driven fusion reveals fast and slow modes of both docking and fusion and intrasample heterogeneity
SM Christensen, MW Mortensen, DG Stamou - Biophysical journal, 2011 - cell.com
Lipid mixing between vesicles functionalized with SNAREs and the cytosolic C2AB domain
of synaptotagmin-1 recapitulates the basic Ca 2+ dependence of neuronal exocytosis …
of synaptotagmin-1 recapitulates the basic Ca 2+ dependence of neuronal exocytosis …
Calcium-dependent regulation of SNARE-mediated membrane fusion by calmodulin
J Di Giovanni, C Iborra, Y Maulet, C Lévêque… - Journal of Biological …, 2010 - ASBMB
Neuroexocytosis requires SNARE proteins, which assemble into trans complexes at the
synaptic vesicle/plasma membrane interface and mediate bilayer fusion. Ca 2+ sensitivity is …
synaptic vesicle/plasma membrane interface and mediate bilayer fusion. Ca 2+ sensitivity is …
Cholesterol facilitates the native mechanism of Ca2+-triggered membrane fusion
MA Churchward, T Rogasevskaia… - Journal of cell …, 2005 - journals.biologists.com
The process of regulated exocytosis is defined by the Ca2+-triggered fusion of two apposed
membranes, enabling the release of vesicular contents. This fusion step involves a number …
membranes, enabling the release of vesicular contents. This fusion step involves a number …
[PDF][PDF] Roles of cholesterol in vesicle fusion and motion
Although it is well established that exocytosis of neurotransmitters and hormones is highly
regulated by numerous secretory proteins, such as SNARE proteins, there is an increasing …
regulated by numerous secretory proteins, such as SNARE proteins, there is an increasing …
Synaptotagmin arrests the SNARE complex before triggering fast, efficient membrane fusion in response to Ca2+
MC Chicka, E Hui, H Liu, ER Chapman - Nature structural & molecular …, 2008 - nature.com
Neuronal communication is mediated by Ca2+-triggered fusion of transmitter-filled synaptic
vesicles with the presynaptic plasma membrane. Synaptotagmin I functions as a Ca2+ …
vesicles with the presynaptic plasma membrane. Synaptotagmin I functions as a Ca2+ …