Targeting of superantigens
T Kalland, M Dohlsten, L Abrahmsén, G Hedlund… - Cell biophysics, 1993 - Springer
The bacterial superantigen staphylococcal enterotoxin A (SEA) is an extremely potent
activator of T lymphocytes when presented on MHC class II antigens. In order to induce T …
activator of T lymphocytes when presented on MHC class II antigens. In order to induce T …
Monoclonal antibody-superantigen fusion proteins: tumor-specific agents for T-cell-based tumor therapy.
M Dohlsten, L Abrahmsen, P Björk… - Proceedings of the …, 1994 - National Acad Sciences
The bacterial superantigen staphylococcal enterotoxin A (SEA) is an extremely potent
activator of T lymphocytes when presented on major histocompatibility complex (MHC) class …
activator of T lymphocytes when presented on major histocompatibility complex (MHC) class …
Superantigen-based tumor therapy: in vivo activation of cytotoxic T cells
G Hedlund, M Dohlsten, C Petersson… - Cancer Immunology …, 1993 - Springer
We have recently demonstrated that the superantigen staphylococcal enterotoxin A (SEA)
targets in vitro activated cytotoxic T lymphocytes against tumor cells expressing major …
targets in vitro activated cytotoxic T lymphocytes against tumor cells expressing major …
Monoclonal antibody-targeted superantigens: a different class of anti-tumor agents.
M Dohlsten, G Hedlund, E Akerblom… - Proceedings of the …, 1991 - National Acad Sciences
The bacterial superantigen staphylococcal enterotoxin (SE) A (SEA) directs cytotoxic T
lymphocytes (CTLs) expressing particular sequences of the T-cell receptor (TCR) beta chain …
lymphocytes (CTLs) expressing particular sequences of the T-cell receptor (TCR) beta chain …
T‐cell stimulation and cytokine release induced by staphylococcal enterotoxin A (SEA) and the SEAD227A mutant
U Holzer, T Orlikowsky, C Zehrer, W Bethge… - …, 1997 - Wiley Online Library
Previous work demonstrated that human cytotoxic T cells activated by superantigens can
lyse major histocompatibility complex (MHC) class II‐positive target cells as well as MHC …
lyse major histocompatibility complex (MHC) class II‐positive target cells as well as MHC …
Identification of the antigenic epitopes in staphylococcal enterotoxins A and E and design of a superantigen for human cancer therapy
E Erlandsson, K Andersson, A Cavallin… - Journal of molecular …, 2003 - Elsevier
Monoclonal antibodies have a potential for cancer therapy that may be further improved by
linking them to effector molecules such as superantigens. Tumor targeting of a superantigen …
linking them to effector molecules such as superantigens. Tumor targeting of a superantigen …
Immunotherapy of human colon cancer by antibody-targeted superantigens
M Dohlsten, PA Lando, P Björk, L Abrahmsén… - Cancer Immunology …, 1995 - Springer
T lymphocytes generally fail to recognize human colon carcinomas, suggesting that the
tumour is beyond reach of immunotherapy. Bacterial superantigens are the most potent …
tumour is beyond reach of immunotherapy. Bacterial superantigens are the most potent …
T cell killing of human colon carcinomas by monoclonal-antibody-targeted superantigens
PA Lando, M Dohlsten, G Hedlund, E Åkerblom… - Cancer Immunology …, 1993 - Springer
The bacterial superantigen staphylococcal enterotoxin A (SEA) induces T cell activation as
well as directing activated T cells to kill major-histocompatibilitycomplex-class-II-expressing …
well as directing activated T cells to kill major-histocompatibilitycomplex-class-II-expressing …
Monoclonal antibodies and superantigens: a novel therapeutic approach
T Kalland, M Dohlsten, P Lind, A Sundstedt… - Medical oncology and …, 1993 - Springer
We have developed a monoclonai antibody (mAb) based therapy intended for the treatment
ofsolid tumors utilizing both main arms of the immune system by incorporating the colon …
ofsolid tumors utilizing both main arms of the immune system by incorporating the colon …
Antibody-targeted superantigens induce lysis of major histocompatibility complex class II-negative T-cell leukemia lines
J Ihle, U Holzer, F Krull, M Dohlsten, T Kalland… - Cancer research, 1995 - AACR
CTLs bearing certain T-cell receptor Vβ-regions are directed by the bacterial superantigen
Staphylococcus enterotoxin A (SEA) to lyse MHC class II-positive cells. In order to extend …
Staphylococcus enterotoxin A (SEA) to lyse MHC class II-positive cells. In order to extend …