Background Pharmacokinetic (PK) and pharmacodynamic (PD) data on perioperative
antibiotic prophylaxis or antibiotic therapy are rare in patients suffering from morbid obesity …

Precision dosing of piperacillin/tazobactam in obese patients is compromised by sparse
information on target-site exposure. We aimed to evaluate the appropriateness of current …

Obesity is a significant global public health concern that is associated with an elevated risk
of comorbidities as well as severe postoperative and nosocomial infections. The treatment of …

Traditionally, there have been uniform antibiotic dosing guidelines for prophylaxis for clean–
clean-contaminated surgery in both non-obese and obese adults. All other factors …

Objectives To assess plasma and tissue pharmacokinetics of cefazolin and metronidazole in
obese patients undergoing bariatric surgery and non-obese patients undergoing intra …

As the prevalence of obesity increases worldwide, clinicians will be more and more
frequently confronted with obese, critically ill patients. Optimal administration of antibiotics is …

Physiologic alterations seen in obesity commonly impact the pharmacokinetics (PK) and
pharmacodynamics (PD) of antibiotics and may result in suboptimal dosing in this …

When almost 60% of the world's population is predicted to be overweight by 2030 [1], dosing
regimens that are developed and tested in non-obese patients will be inappropriate for the …

Ertapenem provides broad-spectrum activity against many pathogens, and its use is relevant
for the prophylaxis and treatment of infections in morbidly obese patients undergoing …

Objectives As morbidly obese patients are prone to surgical site infections, adequate blood
and subcutaneous tissue concentrations of prophylactic antibiotic agents during surgery are …