Pharmacokinetic and pharmacodynamic evaluation of a weight-based dosing regimen of cefoxitin for perioperative surgical prophylaxis in obese and morbidly obese …
P Moine, SW Mueller, JA Schoen… - Antimicrobial Agents …, 2016 - Am Soc Microbiol
The objective of this study was to determine the pharmacokinetics and pharmacodynamics
(PK/PD) of a weight-based cefoxitin dosing regimen for surgical prophylaxis in obese …
(PK/PD) of a weight-based cefoxitin dosing regimen for surgical prophylaxis in obese …
Influence of the obesity phenotype on the adequacy of antibiotic prophylaxis with cefoxitin for obese patients undergoing bariatric surgery: lessons learnt and future …
T Belveyre, J Scala-Bertola, M Esposito, A Luc… - European journal of …, 2021 - Springer
Background and Objectives A high inter-individual variability in pharmacokinetic parameters
in obese patients is observed. The objective of this study was to evaluate the effect of obesity …
in obese patients is observed. The objective of this study was to evaluate the effect of obesity …
Pharmacokinetics and tissue penetration of cefoxitin in obesity: implications for risk of surgical site infection
O Toma, P Suntrup, A Stefanescu, A London… - Anesthesia & …, 2011 - journals.lww.com
BACKGROUND: Obesity is a significant risk factor for surgical site infections (SSIs), for
poorly understood reasons. SSIs are a major cause of morbidity, prolonged hospitalization …
poorly understood reasons. SSIs are a major cause of morbidity, prolonged hospitalization …
Dosing in obese critically ill patients
M Hites, FS Taccone - Antibiotic Pharmacokinetic/Pharmacodynamic …, 2018 - Springer
As the prevalence of obesity continues to rise significantly worldwide, an increasing number
of overweight patients are expected to present to hospital with various pathological …
of overweight patients are expected to present to hospital with various pathological …
[HTML][HTML] Obesity in critically ill patients is associated with increased need of mechanical ventilation but not with mortality
S Tafelski, H Yi, F Ismaeel, A Krannich, C Spies… - Journal of infection and …, 2016 - Elsevier
Worldwide incidence of obesity is increasing and impaired outcome in postoperative
patients has been described. Antibiotic prescribing is complicated by different pharmacology …
patients has been described. Antibiotic prescribing is complicated by different pharmacology …
Repeated Piperacillin-Tazobactam Plasma Concentration Measurements in Severely Obese Versus Nonobese Critically Ill Septic Patients and the Risk of Under–and …
Objective: Obesity and critical illness modify pharmacokinetics of antibiotics, but piperacillin-
tazobactam continuous IV infusion pharmacokinetics has been poorly studied in obese …
tazobactam continuous IV infusion pharmacokinetics has been poorly studied in obese …
[图书][B] Drug dosing in obesity
STR Zaidi, JA Roberts - 2016 - Springer
No matter how depressing it sounds, obesity is here to stay! Despite a significant increase in
the awareness of causes of obesity, extensive media campaign from public health …
the awareness of causes of obesity, extensive media campaign from public health …
One size may not fit all: pondering antibiotic dosing in obesity
HN Polotsky, AJ Polotsky - Maturitas, 2010 - maturitas.org
According to the latest population data, every third patient encountered in the office is
statistically likely to be obese. As prevalence of class III obesity (also referred to as morbid or …
statistically likely to be obese. As prevalence of class III obesity (also referred to as morbid or …
Comprehensive guidance for antibiotic dosing in obese adults: 2022 update
L Meng, E Mui, DR Ha, C Stave… - … : The Journal of …, 2023 - Wiley Online Library
Drug dosing in obese patients continues to be challenging due to a lack of high‐quality
evidence to guide dosing recommendations. We first published guidance for antibiotic …
evidence to guide dosing recommendations. We first published guidance for antibiotic …