Obesity is escalating among children and adults all over the world. This non-communicable
disorder contributes heavily to severe morbidity and mortality in humans due to the …

ABSTRACT A consistent approach to the dosing of aminoglycosides across the modern
body size distribution has been elusive. We evaluated whether radiologically derived …

Obese patients may be at a greater risk for acute kidney injury (AKI) with the use of certain
antimicrobial agents that are dosed by weight. Current preclinical models of AKI utilize the …

Purpose Tobramycin is an aminoglycoside antibiotic of which the 24 h exposure correlates
with efficacy. Recently, we found that clearance of the aminoglycoside gentamicin correlates …

Background: Obesity and commonly associated comorbidities are known risk factors for the
development of infections. However, the intensity and duration of antimicrobial treatment are …

Currently, there is no consensus on whether a standard 2-g prophylactic cefazolin dose
provides sufficient antimicrobial coverage in obese surgical patients. This systematic review …

Monitoring of plasma antibiotic concentrations is necessary for individualization of
antimicrobial chemotherapy dosing in special patient populations. One of these special …

Although the dose of some drugs is commonly adjusted for weight, weight-related dosage
adjustments are rarely made for most antimicrobials. We reviewed the English-language …

Aminoglycoside pharmacokinetics were determined in 30 normal weight patients and 30
morbidly obese patients (> 90% overweight). All had normal renal function and a gram …

Antibiotics such as vancomycin are empirically dosed on the basis of body weight, which
may not be optimal across the expanding adult body size distribution. Our aim was to …