Brain markers of oxidative damage increase with advancing age. In response, brain
antioxidant levels may also increase with age, although this has not been well investigated …

Aging is characterized by a gradual decline of the body's biological functions, which can
lead to increased production of reactive oxygen species (ROS). Antioxidants neutralize ROS …

Significance: A decline in both cognitive and motor functions is one of the characteristics of
aging. This results in changes in learning and memory, as well as deficits in balance and …

For the past 60 years a major theory of “aging” is that age-related damage is largely caused
by excessive uncompensated oxidative stress. The ubiquitous tripeptide glutathione is a …

During aging, the brain is subject to greater oxidative stress (OS), which is thought to play a
critical role in cognitive impairment. Glutathione (GSH), as a major antioxidant in the brain …

Background Extant data from in vivo animal models and postmortem studies indicate that
Alzheimer's disease (AD) pathology is associated with reduction of the brain antioxidant …

Background Mild cognitive impairment (MCI) represents an at-risk state for Alzheimer's
disease in which underlying pathophysiological mechanisms could be delineated. Oxidative …

The antioxidant glutathione (GSH) and pro-oxidant iron levels play a balancing role in the
modulation of oxidative stress (OS). There is a significant depletion of GSH in the left …

The brain is highly susceptible to oxidative stress due to its high metabolic demand.
Increased oxidative stress and depletion of glutathione (GSH) are observed with aging and …

Glutathione (GSH) serves as an important anti-oxidant in the brain by scavenging harmful
reactive oxygen species that are generated during different molecular processes. The GSH …