With millions of older individuals presently suffering from Alzheimer's disease (AD)
worldwide, AD is an unduly common form of dementia that exacts a heavy toll on affected …

Glutathione (GSH) is an important antioxidant implicated in several physiological functions,
including the oxidation− reduction reaction balance and brain antioxidant defense against …

Decrements in motor and cognitive function occur in aging, possibly due to oxidative stress-
induced damage to the brain. Declines in antioxidant defense mechanisms have been …

Oxidative stress and mitochondrial damage are implicated in the evolution of
neurodegenerative diseases. Increased oxidative damage in specific brain regions during …

Background Redox signaling, which can be assessed by circulating aminothiols, reflects
oxidative stress (OS) status and has been linked to clinical cardiovascular disease and its …

Loss of brain glutathione has been associated with cognitive decline and neuronal death
during aging and neurodegenerative diseases. However, whether decreased glutathione …

Aging is an extremely complex, multifactorial process that is characterized by a gradual and
continuous loss of physiological functions and responses, particularly marked in the brain. A …

Glutathione is a remarkably functional molecule with diverse features, which include being
an antioxidant, a regulator of DNA synthesis and repair, a protector of thiol groups in …

Oxidative stress is implicated in the pathogenesis of many neurodegenerative diseases,
including Parkinson's disease and Alzheimer's disease. The depletion of glutathione (GSH) …

Glutathione (GSH) is a major endogenous antioxidant. Several studies have shown GSH
redox imbalance and altered GSH levels in Alzheimer's disease (AD) patients. Early …