Normal aging involves a gradual breakdown of physiological processes that leads to a
decline in cognitive functions and brain integrity, yet the onset and progression of decline …

As human society ages globally, age-related disorders are becoming increasingly common.
Due to decreasing physiological reserves and increasing organ system dysfunction …

The spinal cord motor nuclei have been the focus of a number of investigations exploring
neurodegenerative mechanisms, eg excitotoxicity mediated by glutamate and oxidative …

Oxidative damage in the brain may lead to cognitive impairments in aged humans. Further,
in age-associated neurodegenerative disease, oxidative damage may be exacerbated and …

Objectives. Oxidative stress contributes to Parkinson's disease (PD) pathophysiology and
progression. The objective was to describe central and peripheral metabolites of redox …

Glutathione is an important antioxidant in the brain that appears to be decreased, in
conjunction with mitochondrial complex I activity, in Parkinson disease patients. In …

We measured total glutathione concentrations in the cerebrospinal fluid (CSF) of non-
demented Parkinson's disease patients (PD; n= 71), demented PD patients (PDD; n= 13) …

Glutathione is a ubiquitous antioxidant that protects cells against reactive oxygen species
and other chemical stressors. Despite its functional importance, the impact of genetics on the …

Normal aging is associated with numerous biological changes, including altered brain
metabolism and tissue chemistry. In vivo characterization of the neurochemical profile during …

The aging brain is associated with atrophy along with functional and metabolic changes. In
this study, we examined age-related changes in resting brain functions and the vulnerability …