Comparing the reproducibility of commonly used magnetic resonance spectroscopy techniques to quantify cerebral glutathione
SA Wijtenburg, J Near, SA Korenic… - Journal of Magnetic …, 2019 - Wiley Online Library
Background Cerebral glutathione (GSH), a marker of oxidative stress, has been quantified in
neurodegenerative diseases and psychiatric disorders using proton magnetic resonance …
neurodegenerative diseases and psychiatric disorders using proton magnetic resonance …
[引用][C] Glutathione metabolism and oxidative stress in neurodegeneration
R Dringen - European Journal of Biochemistry, 2000 - Wiley Online Library
Oxidative stress occurs as a consequence of an alteration in the equilibrium of the
production of reactive oxygen species and antioxidative processes in favor of the production …
production of reactive oxygen species and antioxidative processes in favor of the production …
Chronic antioxidant treatment improves the cognitive performance of aged rats
DJ Socci, BM Crandall, GW Arendash - Brain research, 1995 - Elsevier
Free radicals and oxidative damage have been implicated in brain aging and several
neurodegenerative diseases. The purpose of the present study was to determine whether …
neurodegenerative diseases. The purpose of the present study was to determine whether …
Oxidative stress levels in the brain are determined by post-mortem interval and ante-mortem vitamin C state but not Alzheimer's disease status
The current study highlighted several changes in measures of oxidative stress and
antioxidant status that take place in the mouse brain over the course of 24 h post-mortem …
antioxidant status that take place in the mouse brain over the course of 24 h post-mortem …
The influence of vitamins E and C and exercise on brain aging
Age-related declines in motor and cognitive function have been associated with increases in
oxidative stress. Accordingly, interventions capable of reducing the oxidative burden would …
oxidative stress. Accordingly, interventions capable of reducing the oxidative burden would …
Late onset administration of oral antioxidants prevents age-related loss of motor co-ordination and brain mitochondrial DNA damage
FV Pallardó, M Asensi… - Free radical …, 1998 - Taylor & Francis
We have studied the effect of aging on brain glutathione redox ratio, on brain mitochondrial
DNA damage and on motor co-ordination in mice and the possible protective role of late …
DNA damage and on motor co-ordination in mice and the possible protective role of late …
Age-related losses of cognitive function and motor skills in mice are associated with oxidative protein damage in the brain.
MJ Forster, A Dubey, KM Dawson… - Proceedings of the …, 1996 - National Acad Sciences
The hypothesis that age-associated impairment of cognitive and motor functions is due to
oxidative molecular damage was tested in the mouse. In a blind study, senescent mice …
oxidative molecular damage was tested in the mouse. In a blind study, senescent mice …
Decline in glutathione peroxidase activity is a reason for brain senescence: consumption of green tea catechin prevents the decline in its activity and protein oxidative …
T Kishido, K Unno, H Yoshida, D Choba, R Fukutomi… - Biogerontology, 2007 - Springer
The accumulation of oxidative damage is believed to contribute to senescence. We have
previously found that the consumption of green tea catechins (GT-catechin), which are …
previously found that the consumption of green tea catechins (GT-catechin), which are …
In-vivo glutathione elevation protects against hydroxyl free radical-induced protein oxidation in rat brain
CB Pocernich, M La Fontaine, DA Butterfield - Neurochemistry international, 2000 - Elsevier
Glutathione deficiency has been associated with a number of neurodegenerative diseases
including Lou Gehrig's disease, Parkinson's disease, and HIV. A crucial role for glutathione …
including Lou Gehrig's disease, Parkinson's disease, and HIV. A crucial role for glutathione …
Noninvasive quantification of ascorbate and glutathione concentration in the elderly human brain
In this study, ascorbate (Asc) and glutathione (GSH) concentrations were quantified
noninvasively using double‐edited 1H MRS at 4 T in the occipital cortex of healthy young …
noninvasively using double‐edited 1H MRS at 4 T in the occipital cortex of healthy young …