The arachnoid barrier delineates the border between the central nervous system and dura
mater. Although the arachnoid barrier creates a partition, communication between the …

The concept of immune privilege suggests that the central nervous system is isolated from
the immune system. However, recent studies have highlighted the borders of the central …

Alzheimer's disease (AD) is the most prevalent cause of dementia. Although there is no
effective treatment for AD, passive immunotherapy with monoclonal antibodies against …

The central nervous system is lined by meninges, classically known as dura, arachnoid, and
pia mater. We show the existence of a fourth meningeal layer that compartmentalizes the …

The meninges, comprising the leptomeninges (pia and arachnoid layers) and the
pachymeninx (dura layer), participate in central nervous system (CNS) autoimmunity, but …

INTRODUCTION Myeloid cells are highly heterogeneous, with distinct ontogenies and
immune functions. The diverse role of myeloid populations, including monocytes …

Macrophages are important players in the maintenance of tissue homeostasis. Perivascular
and leptomeningeal macrophages reside near the central nervous system (CNS) …

Despite the importance of the cerebrovasculature in maintaining normal brain physiology
and in understanding neurodegeneration and drug delivery to the central nervous system …

Recent work has shown that meningeal lymphatic vessels (mLVs), mainly in the dorsal part
of the skull, are involved in the clearance of cerebrospinal fluid (CSF), but the precise route …

The central nervous system has historically been viewed as an immune-privileged site, but
recent data have shown that the meninges—the membranes that surround the brain and …