Amylin and amylin receptors in Alzheimer's disease
W Fu, JH Jhamandas - Genetics, Neurology, Behavior, and Diet in …, 2020 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by
early and sustained accumulation of β-amyloid (Aβ) protein in the brain. Current treatments …
early and sustained accumulation of β-amyloid (Aβ) protein in the brain. Current treatments …
Amylin receptor: a potential therapeutic target for Alzheimer's disease
W Fu, A Patel, R Kimura, R Soudy… - Trends in Molecular …, 2017 - cell.com
Alzheimer'sdisease (AD) is a progressive neurodegenerative disorder, characterized by
senile plaques constituting extracellular deposits of β-amyloid (Aβ) fibrils. Since Aβ …
senile plaques constituting extracellular deposits of β-amyloid (Aβ) fibrils. Since Aβ …
Short amylin receptor antagonist peptides improve memory deficits in Alzheimer's disease mouse model
Recent evidence supports involvement of amylin and the amylin receptor in the
pathogenesis of Alzheimer's disease (AD). We have previously shown that amylin receptor …
pathogenesis of Alzheimer's disease (AD). We have previously shown that amylin receptor …
[HTML][HTML] Amylin and its analogs: a friend or foe for the treatment of Alzheimer's disease?
WQ Qiu, H Zhu - Frontiers in aging neuroscience, 2014 - frontiersin.org
Amylin, a gut-brain axis hormone, and amyloid-beta peptides (Aβ), a major component of the
Alzheimer's disease (AD) brain, share several features, including similar β-sheet secondary …
Alzheimer's disease (AD) brain, share several features, including similar β-sheet secondary …
Amylin and its G-protein-coupled receptor: A probable pathological process and drug target for Alzheimer's disease
WQ Qiu - Neuroscience, 2017 - Elsevier
G-protein-coupled receptors (GPCRs) are shown to be involved in Alzheimer's disease (AD)
pathogenesis. However, because GPCRs include a large family of membrane receptors, it is …
pathogenesis. However, because GPCRs include a large family of membrane receptors, it is …
Role of amylin and its receptors in neurodegeneration
W Fu, JH Jhamandas - Current Protein and Peptide Science, 2013 - ingentaconnect.com
Amylin (islet amyloid polypeptide) and amyloid beta protein (Aβ), identified as proteinaceous
deposits within the pancreas of diabetics and the brain of Alzheimer's patients respectively …
deposits within the pancreas of diabetics and the brain of Alzheimer's patients respectively …
Amylin receptor ligands reduce the pathological cascade of Alzheimer's disease
Amylin is an important gut-brain axis hormone. Since amylin and amyloid-β peptide (Aβ)
share similar β sheet secondary structure despite not having the same primary sequences …
share similar β sheet secondary structure despite not having the same primary sequences …
[HTML][HTML] Amylin receptor: a common pathophysiological target in Alzheimer's disease and diabetes mellitus
W Fu, A Patel, JH Jhamandas - Frontiers in aging neuroscience, 2013 - frontiersin.org
Amylin (islet amyloid polypeptide) and amyloid-beta (Aβ) protein, which are deposited within
pancreatic islets of diabetics and brains of Alzheimer's patients respectively, share many …
pancreatic islets of diabetics and brains of Alzheimer's patients respectively, share many …
[HTML][HTML] Amylin pharmacology in Alzheimer's disease pathogenesis and treatment
RR Corrigan, H Piontkivska… - Current …, 2022 - ncbi.nlm.nih.gov
The metabolic peptide hormone amylin, in concert with other metabolic peptides like insulin
and leptin, has an important role in metabolic homeostasis and has been intimately linked to …
and leptin, has an important role in metabolic homeostasis and has been intimately linked to …
[HTML][HTML] Cyclic AC253, a novel amylin receptor antagonist, improves cognitive deficits in a mouse model of Alzheimer's disease
R Soudy, A Patel, W Fu, K Kaur, D MacTavish… - Alzheimer's & Dementia …, 2017 - Elsevier
Introduction Amylin receptor serves as a portal for the expression of deleterious effects of
amyloid β-protein (Aβ), a key pathologic hallmark of Alzheimer's disease. Previously, we …
amyloid β-protein (Aβ), a key pathologic hallmark of Alzheimer's disease. Previously, we …