Amylin and amylin receptors in Alzheimer's disease

W Fu, JH Jhamandas - Genetics, Neurology, Behavior, and Diet in …, 2020 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by
early and sustained accumulation of β-amyloid (Aβ) protein in the brain. Current treatments …

Amylin receptor: a potential therapeutic target for Alzheimer's disease

W Fu, A Patel, R Kimura, R Soudy… - Trends in Molecular …, 2017 - cell.com
Alzheimer'sdisease (AD) is a progressive neurodegenerative disorder, characterized by
senile plaques constituting extracellular deposits of β-amyloid (Aβ) fibrils. Since Aβ …

Short amylin receptor antagonist peptides improve memory deficits in Alzheimer's disease mouse model

R Soudy, R Kimura, A Patel, W Fu, K Kaur… - Scientific Reports, 2019 - nature.com
Recent evidence supports involvement of amylin and the amylin receptor in the
pathogenesis of Alzheimer's disease (AD). We have previously shown that amylin receptor …

[HTML][HTML] Amylin and its analogs: a friend or foe for the treatment of Alzheimer's disease?

WQ Qiu, H Zhu - Frontiers in aging neuroscience, 2014 - frontiersin.org
Amylin, a gut-brain axis hormone, and amyloid-beta peptides (Aβ), a major component of the
Alzheimer's disease (AD) brain, share several features, including similar β-sheet secondary …

Amylin and its G-protein-coupled receptor: A probable pathological process and drug target for Alzheimer's disease

WQ Qiu - Neuroscience, 2017 - Elsevier
G-protein-coupled receptors (GPCRs) are shown to be involved in Alzheimer's disease (AD)
pathogenesis. However, because GPCRs include a large family of membrane receptors, it is …

Role of amylin and its receptors in neurodegeneration

W Fu, JH Jhamandas - Current Protein and Peptide Science, 2013 - ingentaconnect.com
Amylin (islet amyloid polypeptide) and amyloid beta protein (Aβ), identified as proteinaceous
deposits within the pancreas of diabetics and the brain of Alzheimer's patients respectively …

Amylin receptor ligands reduce the pathological cascade of Alzheimer's disease

H Zhu, X Xue, E Wang, M Wallack, H Na, JM Hooker… - …, 2017 - Elsevier
Amylin is an important gut-brain axis hormone. Since amylin and amyloid-β peptide (Aβ)
share similar β sheet secondary structure despite not having the same primary sequences …

[HTML][HTML] Amylin receptor: a common pathophysiological target in Alzheimer's disease and diabetes mellitus

W Fu, A Patel, JH Jhamandas - Frontiers in aging neuroscience, 2013 - frontiersin.org
Amylin (islet amyloid polypeptide) and amyloid-beta (Aβ) protein, which are deposited within
pancreatic islets of diabetics and brains of Alzheimer's patients respectively, share many …

[HTML][HTML] Amylin pharmacology in Alzheimer's disease pathogenesis and treatment

RR Corrigan, H Piontkivska… - Current …, 2022 - ncbi.nlm.nih.gov
The metabolic peptide hormone amylin, in concert with other metabolic peptides like insulin
and leptin, has an important role in metabolic homeostasis and has been intimately linked to …

[HTML][HTML] Cyclic AC253, a novel amylin receptor antagonist, improves cognitive deficits in a mouse model of Alzheimer's disease

R Soudy, A Patel, W Fu, K Kaur, D MacTavish… - Alzheimer's & Dementia …, 2017 - Elsevier
Introduction Amylin receptor serves as a portal for the expression of deleterious effects of
amyloid β-protein (Aβ), a key pathologic hallmark of Alzheimer's disease. Previously, we …