Osteoporosis is a bone disease characterized by brittle bone and increased fracture
incidence. With ageing societies worldwide, the disease presents a high burden on health …

Background Mechanotransduction in bone cells plays a pivotal role in osteoblast
differentiation and bone remodelling. Mechanotransduction provides the link between …

Osteoblasts are key components of the bone multicellular unit and have a seminal role in
bone remodeling, which is an essential function for the maintenance of the structural …

Significance: Mechanosignaling is vital for maintaining the structural integrity of bone under
physiologic conditions. These signals activate and suppress multiple signaling cascades …

Bones are constantly exposed to mechanical forces from both muscles and Earth's gravity to
maintain bone homeostasis by stimulating bone formation. Mechanotransduction transforms …

Osteoporosis (OP) is a major health problem in society. OP is characterised by low bone
mass and deterioration of bone strength, resulting in fragile bones which are more prone to …

This chapter reviews the state of knowledge with respect to skeletal mechanobiology. Forms
of tissue-level mechanical stimulation are first described, including electromagnetic fields …

The skeleton is subject to dynamic changes throughout life and bone remodeling is
essential for maintenance of bone functionality. The cell populations which predominantly …

Bone cells are a series of basic units that make up rigid bone tissue and can sense external
mechanical stimuli and generate corresponding intracellular regulatory signals. This …

Bone is one of the most adaptable tissues in the body as it is continuously subjected to load
bearing. In fact, mechanical loading is an important regulator of bone mass. The skeleton …