The Anticoagulant Systems Cooperate Synergistically on Phospholipid Vesicle and Endothelial Cell Membranes, but Not on Platelets

MMS Sim, DFD Mahmood, JP Wood - Blood, 2023 - Elsevier
Introduction: Thrombin, the enzyme which converts fibrinogen into a fibrin clot, is produced
by the prothrombinase complex, composed of factor Xa (FXa) and factor Va (FVa). Down …

Dataset supporting paper'Dietary n-3 polyunsaturated fatty acids alter the number, fatty acid profile and coagulatory activity of circulating and platelet-derived …

R Zhou, E Bozbas - 2023 - researchdata.reading.ac.uk
This dataset includes all reports and summaries of raw data supporting the results presented
in the paper" Dietary n-3 polyunsaturated fatty acids alter the number, fatty acid profile and …

Differential associations between lipid-lowering drugs, statins and fibrates, and venous thromboembolism: role of drug induced homocysteinemia?

K Lacut, G Le Gal, JH Abalain, D Mottier, E Oger - Thrombosis research, 2008 - Elsevier
BACKGROUND: Previous studies reported that statin use was associated with a decreased
risk of venous thromboembolism (VTE), whereas no association was found between fibrate …

Comparison of assays measuring extracellular vesicle-tissue factor in plasma samples: Communication from the ISTH SSC Subcommittee on Vascular Biology.

A Bonifay, N Mackman, Y Hisada, ATA Sachetto… - Journal of Thrombosis …, 2024 - Elsevier
Background Scientific and clinical interest in extracellular vesicles (EVs) is growing. EVs that
expose tissue factor (TF) bind factor VII/VIIa and can trigger coagulation. Highly …

Phosphatidylserine exposing extracellular vesicles in pre-eclamptic patients

S Lalic-Cosic, V Dopsaj, M Kovac… - Frontiers in …, 2021 - frontiersin.org
Background: Pre-eclampsia (P-EC) is associated with systemic inflammation, endothelial
dysfunction and hypercoagulability. The role of extracellular vesicles (EVs) in coagulation …

Decreased procoagulant phospholipids in patients treated by vitamin K antagonists

A Rousseau, B Woodhams, M Paunet-Bobo… - Thrombosis research, 2012 - Elsevier
INTRODUCTION: The stimulation of cells by thrombin is associated with the release of
microparticles (MPs) from cell membranes. These MPs can express procoagulant activity. As …

Lipids metabolism: lipids and lipoproteins–effect on blood clotting and risk of venous thrombosis

LB Nielsen, SK Moestrup - Current opinion in lipidology, 2006 - journals.lww.com
Despite sharing a similar biochemical endpoint, the known risk factors for venous and
arterial thrombosis are quite different. Arterial thrombosis is closely linked to atherosclerosis …

Leukocyte-and platelet-derived microparticles correlate with thrombus weight and tissue factor activity in an experimental mouse model of venous thrombosis

E Ramacciotti, AE Hawley, DM Farris… - Thrombosis and …, 2009 - thieme-connect.com
Microparticles (MP) are lipid vesicles from platelets, leukocytes and endothelial cells that are
involved in early thrombogenesis. We evaluated a detailed time-course analysis of MPs on …

Comprehensive platelet phenotyping supports the role of platelets in the pathogenesis of acute venous thromboembolism–results from clinical observation studies

M Panova-Noeva, B Wagner, M Nagler, T Koeck… - …, 2020 - thelancet.com
Background The pathogenesis of arterial and venous thrombosis is in large part interlaced.
How much platelet phenotype relates to acute venous thromboembolism (VTE) independent …

Extracellular Vesicles: Intercellular Communication Mediators in Antiphospholipid Syndrome

U Štok, S Čučnik, S Sodin-Šemrl, P Žigon… - … -Recent Advances in …, 2021 - books.google.com
Antiphospholipid syndrome (APS) is a systemic autoimmune disease characterized by
thrombosis, obstetric complications and the presence of antiphospholipid antibodies (aPL) …