Phosphorylation of N-methyl-d-aspartate receptor (NMDAR) is widely regarded as a vital
modification of synaptic function. Various protein kinases are responsible for direct …

Chronic pain, especially neuropathic pain resulting from damage to the peripheral or central
nervous system, is a major clinical problem that remains difficult to treat. The glutamate N …

Neuropathic pain remains a major clinical problem and a therapeutic challenge because
existing analgesics are often ineffective and can cause serious side effects. Increased N …

Chronic neuropathic pain is a debilitating condition that remains challenging to treat.
Glutamate N-methyl-d-aspartate receptor (NMDAR) antagonists have been used to treat …

For decades, N-methyl-D-aspartate (NMDA) receptors have been known to play a critical
role in the modulation of both acute and chronic pain. Of particular interest are NMDA …

Neuropathic pain, generally defined as a chronic pain state resulting from peripheral or
central nerve injury, can devastate the lives of patients and their families and friends. The …

Studies have shown that N-methyl-d-aspartate (NMDA) receptors play a critical role in pain
processing at different levels of the central nervous system. In this study, we used cortex …

The N-methyl-d-aspartate receptor (NMDAR) contributes to central sensitization in the spinal
cord, a phenomenon which comprises various pathophysiological mechanisms responsible …

Basic research on pain and pain modulation is unique among many branches of biomedical
research in that objective measures such as nociceptive responses to thermal or mechanical …

The N-methyl-d-aspartate subtype of excitatory amino acid receptor is abundantly distributed
throughout the central nervous system and is intimately associated with physiologic …